3-​(p-​Bromophenyl)​-​3-​(2-​pyridyl)​-​N,​N-​dimethylpropylamine maleate N,N-二甲基-gamma-(4-溴苯基)-2-吡啶丙胺顺丁烯二酸盐

CAS 980-71-2 MFCD00057367

化学结构图

980-71-2
SMILES: CN(C)CCC(c1ccc(Br)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O

化学属性

Mol. FormulaC20H23BrN2O4
Mol. Weight435
SolubilityDMSO mg/mL Water mg/mL Ethanol mg/mL
Melting Point134.0 to 138.0 deg-C

别名和识别编码

Chemical Name3-​(p-​Bromophenyl)​-​3-​(2-​pyridyl)​-​N,​N-​dimethylpropylamine maleate
MDL NumberMFCD00057367
PubChem Substance ID5281067
EC Number213-562-9
Synonym (+/-)-BROMPHENIRAMINE MALEATE SALT 1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate 1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1) 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1) 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1) 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, 3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine BROMOPHENIRAMINE MALEATE BROMPHENIRAMINE MALEATE BROMPHENIRAMINE MALEATE SALT Bromopheniramine maleate Brompheniramine Brompheniramine Maleate Brompheniramine Maleate (1:1) Brompheniramine male
CAS Number980-71-2
Chemical Name TranslationN,N-二甲基-gamma-(4-溴苯基)-2-吡啶丙胺顺丁烯二酸盐
Wiswesser Line NotationT6NJ BYR DE&2N1&1
Reaxys-RN4117058
Merck Number1443
LabNetwork Molecule IDLN01278500
InChIInChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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分类

  • {SA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards

相关文献及参考

  • [2]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65.
  • [1]. Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544.
  • [1]. Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544.
  • [2]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65.

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSUS4025000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Packing GroupIII
Hazard Codes Xn Xn,Xi
Hazard Class6.1(b)
UN Number 3249
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition 储存温度-20°C
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 318 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,19,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 76 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,19,1969

其他信息

  • 图谱信息:马来酸溴苯那敏(980-71-2)红外图谱(IR1) 马来酸溴苯那敏(980-71-2)红外图谱(IR2) 马来酸溴苯那敏(980-71-2)质谱(MS)
  • 类别:有毒物质
  • 毒性分级:高毒
  • 储运特性:库房通风低温干燥; 与食品原料类分开存放
  • 可燃性危险特性:热分解排出有毒氮氧化物和溴化物,氯化氢烟雾
  • 灭火剂:水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • Brompheniramine maleate solution
  • MOL 文件:980-71-2.mol
  • 急性毒性:口服-大鼠 LD50: 318 毫克/公斤; 腹腔-大鼠 LD50: 76 毫克/公斤

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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