Fentanyl citrat Fentanyl

CAS 990-73-8 MFCD00058359

化学结构图

990-73-8
SMILES: CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O

化学属性

Mol. FormulaC22H28N2O.C6H8O7
Mol. Weight528.66
Flash Point11 °C
Appearance 白色结晶性粉末。熔点149-151℃。1g该品可溶于约40ml水，溶于甲醇，略溶于氯仿。无臭，味苦。芬太尼碱（[437-38-7]）熔点83-84℃。
Melting Point153-156°C

别名和识别编码

Chemical NameFentanyl citrat
CAS Number990-73-8
Synonym Duragesic Durogesic FENTANYL CITRATE FENTANYL CITRATE 100 UG PER ML*IN MEOH-T -BUOH METHA FENTANYL CITRATE SALT FENTANYL CITRATE--DEA SCHEDULE II FENTANYL DIHYDROGEN CITRATE Fentanest Fentanyl Fentanyl Citrate Fentanyl citrate Fentanyl citrate salt FentanylCitrate[Dd] Fentaz Fentora Leptanal Leptanal citrate Leptanol McN-JR 4263 McN-JR-4263-49 N-(1-Phenethyl-4-piperidinyl)propionanilide dihydrogen citrate N-(1-Phenethyl-4-piperidyl)propionanilide citrate N-(1-Phenethyl-4-piperidyl)propionanilide dihydrogen citrate N-(Phenyl)-N-(1-[2-phenylethyl]-4-piperidinyl)propanamide Citrate N-(Phenyl)-N-(1-[2-phenylethyl]-4-piperidinyl)propanamide citrate N-PHENYL-N-[1-(2-PHENYLETHY
MDL NumberMFCD00058359
EC Number213-588-0
Chemical Name TranslationFentanyl
Wiswesser Line NotationT6NTJ A2R& DNR&V2 &OV1XQVO&1VO
PubChem Substance ID13810
InChIInChI=1S/C22H28N2O.C6H8O7/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-12,21H,2,13-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids - Opiod Agonists, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neurobiology, Neuroscience, Opioid Agonists, Opioids, Pharmacologicals, Proteins and Derivatives

产品应用

  • Used as an analgesic. Controlled substance

相关文献及参考

  • Zernig, G., et al.: Life Sci., 57, 2113 (1995),
  • Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998),

安全信息

GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P301+P310
  • P302+P350
  • P302+P352
  • P304+P340
  • P304+P341
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P333+P313
  • P342+P311
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H330 Fatal if inhaled 吸入致命
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSUE5600000
Hazard Codes T+ T+,T,F
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R42/43
  • R11 Highly flammable 非常易燃
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
Packing GroupIII
Hazard Class6.1(b)
Storage condition 2-8°C
UN Number UN 2811 6.1/PG 2
Restrict 精麻类化学品 {} 麻醉药品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 990 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,666,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5460 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,666,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 15 ug/kg/7M-C
TOXIC EFFECTS :
   Beha

{hazard_

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,666,1982

TYPE OF TEST            : LD50 - Lethal dose, 50

其他信息

  • Sigma Aldrich:990-73-8(sigmaaldrich)
  • 用途一:该品药理作用同吗啡，镇痛效力约为吗啡的150倍，为短时间的镇痛剂，与氟哌利多联合应用称为安定镇痛术。用于诱导麻醉。临床主要用于外科手术前和手术中镇痛，胃镜和泌尿系统检查之镇痛。
  • MOL 文件:990-73-8.mol
  • 方法一:由苯乙胺经加成、环合、缩合、还原、丙酰化制成芬太尼碱，与枸椽酸成盐得成品。
  • 上游原料:柠檬酸

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. F - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Membrane Protein Biology Tools - Proteins and Derivatives
  5. GPCR Proteins, Modulators and Antibodies - Membrane Protein Biology Tools
  6. GPCR Modulators - GPCR Proteins, Modulators and Antibodies
  7. Excitatory Amino Acids - Opiod Agonists - GPCR Modulators
  1. Functional Group 官能团索引
  2. alpha-hydroxyacid

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