VDA

下级目录

Crolibulin
AZD-6126
OXi8007
Plinabulin
Verubulin
STA-9584
BNC105
BNC105P
DMXAA

目录项下的产品

1000852-17-4
219923-05-4
288847-41-6
714272-27-2
827031-83-4
906481-23-0
945771-74-4
945771-96-0
945771-96-0 / MFCD045771960
BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.
[6-甲氧基-2-甲基-7-(磷酰氧基)-3-苯并呋喃基](3,4,5-三甲氧基苯基)甲酮钠盐
117570-53-3