CFTR

下级目录

Tezacaftor

IOWH032

VX-770

PPQ-102

(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE

Lumacaftor

目录项下的产品

1152311-62-0

1152311-62-0 / MFCD252311620
(R)-1-(2,2-Difluorobenzo[D][1,3]Dioxol-5-Yl)-N-(1-(2,3-Dihydroxypropyl)-6-Fluoro-2-(1-Hydroxy-2-Methylpropan-2-Yl)-1H-Indol-5-Yl)Cyclopropanecarboxamide
1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1191252-49-9

1191252-49-9 / MFCD291252499
IOWH032 is a CFTR inhibitor. Diarrhea, a disease of poverty and poor sanitation, kills an estimated two million children each year. Oral rehydration therapy is a very simple and inexpensive treatment that has significantly reduced mortality from secretory diarrhea caused by rotavirus, cholera and enterotoxigenic Escherichia coli. The efficacy and adoption of oral rehydration therapy would be enhanced by a drug that reduces fluid loss associated with these diseases and alleviates disease symptoms. Secretion and absorption by the intestine offer a number of potential drug targets to reduce fluid loss.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

873054-44-5

873054-44-5 / MFCD73054445
Ivacaftor
依伐卡托

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

931706-15-9

931706-15-9 / MFCD031706159
7,9-Dimethyl-6-(5-Methylfuran-2-Yl)-11-Phenyl-6,7-Dihydropyrimido[4',5':3,4]Pyrrolo[1,2-A]Quinoxaline-8,10(5H,9H)-Dione
7,9-二甲基-6-(5-甲基呋喃-2-基)-11-苯基-5,6-二氢嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(7H,9H)-二酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

328541-79-3

328541-79-3 / MFCD01532954
GlyH-101 is a CFTR inhibitor (cystic fibrosis transmembrane conductance regulator). GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels. GlyH-101 blocked I(Cl.PKA) in a concentration- and voltage-dependent fashion (IC(50) at +100 mV=0.3 Â± 1.5 μM and at -100 mV=5.1 Â± 1.3 μM). GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â± 0.03 from the external membrane surface.
N’-(3,5-二溴-2,4-二羟基亚苄基)-2-(萘-2-基氨基)乙酰肼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

936727-05-8

936727-05-8 / MFCD16659051
3-(6-(1-(2,2-Difluorobenzo[d][1,3]Dioxol-5-Yl)Cyclopropanecarboxamido)-3-Methylpyridin-2-Yl)Benzoic Acid
3-(6-(1-(2,2-二氟苯并[d][1,3]二氧杂环己烷基-5-基)环丙烷甲酰胺)-3-甲基吡啶-2-基)苯甲酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

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