Dideoxyadenosine 2,3-双脱氧腺苷

CAS 4097-22-7 MFCD00010534

化学结构图

4097-22-7
SMILES: Nc1ncnc2c1ncn2C1CCC(CO)O1

化学属性

Mol. FormulaC10H13N5O2
Mol. Weight235
Density1.422
Melting Point181-184
TSCANo
Refractive index-34 ° (C=1, H2O)

别名和识别编码

Chemical NameDideoxyadenosine
CAS Number4097-22-7
Synonym 2',3'-DIDEOXYADENOSINE 2',3'-DIDEOXYADENOSINE extapure 2',3'-Dideoxy-D-adenosine 2',3'-Dideoxy-adenosine 2',3'-Dideoxyadenosine ddA 2',3'-二脱氧腺苷 2',3'-二脱氧腺苷 2,3-二脱氧腺苷 二脱氧腺(嘌呤核)苷 2',3'-双脱氧腺苷 2',3'-双脱氧腺甙 双脱氧腺嘌呤核苷 2,3-二脱氧腺苷 2’,3’-dideoxy-adenosin 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine BETA-D-2',3'-DIDEOXYADENOSINE DDA DIDEOXYADENOSINE NSC 98700 NSC-98700 [(2S,5R)-5-(6-Aminopurin-9-yl)oxolan-2-yl]methanol ddA ddA,9-(2,3-Dideoxy--D-ribofuranosyl)adenine ddA,9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine 二脱氧腺(嘌呤核)苷 双脱氧腺嘌呤核苷
EC Number223-853-2
Beilstein Registry Number619924
MDL NumberMFCD00010534
PubChem Substance ID20039
Merck Number3101
Chemical Name Translation2,3-双脱氧腺苷
Reaxys-RN619924
LabNetwork Molecule IDLN00196099
InChIInChI=1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1
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分类

  • Bases & Related Reagents
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Nucleoside Analogs, 核苷,核苷酸和寡核苷酸, 生化试剂
  • Nucleotides
  • Carbohydrates & Derivatives
  • {SNA} An
  • Heterocycles
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards,
  • Pharmaceuticals
  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
  • Intermediates & Fine Chemicals
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, D-DIF, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides

产品应用

  • A potent anti-HIV agent.

相关文献及参考

  • Pearlman, D., et al.: J. Mol. Biol., 220, 457 (1991),
  • Cappellacci, L., et al.: J. Med. Chem., 45, 1196 (2002),

安全信息

Signal word Warning
GHS Symbol
WGK Germany2
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSAU7358900
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
Storage condition 存储温度2-8°C 2-8°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Serratia marcescens
DOSE/DURATION           : 144 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 37 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 19 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Micr

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 9 gm/kg/3D (Continuous)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   18,168,1991

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 30 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 181 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 19,424,1981

其他信息

  • TCI Shanghai:2',3'-二脱氧腺苷 2',3'-Dideoxyadenosine,>;98.0%(LC)(T)(4097-22-7)
  • MOL 文件:4097-22-7.mol
  • MSDS 信息:2',3'-Dideoxy-adenosine(4097-22-7).msds
  • 用途一:用作抗病毒药
  • 2',3'-双脱氧腺苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 D3065 2',3'-二脱氧腺苷 2',3'-Dideoxyadenosine 1G 9980元
  • Sigma Aldrich:4097-22-7(sigmaaldrich)

系列性分类


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