N-Methyl-N-Propargylbenzylamine Hydrochloride N-苄基-N-甲基丙-2-炔-1-胺盐酸盐
CAS 306-07-0 MFCD00012492
化学结构图
SMILES: C#CCN(C)Cc1ccccc1.Cl
化学属性
| Mol. Formula | C11H14ClN |
|---|---|
| Mol. Weight | 196 |
| Melting Point | 160-163 °C(lit.) |
别名和识别编码
| Chemical Name | N-Methyl-N-Propargylbenzylamine Hydrochloride |
|---|---|
| Synonym | N-甲基-N-丙炔基苄胺 盐酸盐 Pargyline chloride USAF A-19120 N-Methyl-N-(2-propynyl)benzylamine hydrochloride Benzylmethylpropynylamine hydrochloride N-甲基-N-2-丙炔基苄胺 盐酸盐 N-甲基-N-丙炔基苄胺 盐酸盐 优降宁 盐酸盐 2-Propynylamine, N-benzyl-N-methyl-, hydrochloride MO 911 巴吉林盐酸盐,丙炔甲基苄胺,帕吉林,巴吉林 A 19120 N-Benzyl-N-methyl-2-propynylamine hydrochloride N-甲基-N-2-丙炔基苄胺 盐酸盐 优降宁 Pargyline hydrochloride Eudatin |
| CAS Number | 306-07-0 |
| PubChem Substance ID | 9373 |
| EC Number | 206-175-1 |
| Beilstein Registry Number | 3699487 |
| MDL Number | MFCD00012492 |
| Chemical Name Translation | N-苄基-N-甲基丙-2-炔-1-胺盐酸盐 |
| Wiswesser Line Notation | 1UU2N1&1R &GH |
| LabNetwork Molecule ID | LN01289095 |
| InChI | InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H |
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分类
- Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epigenetics, Histone Lysine Demethylase Inhibitors, Histone Methylation Modulators, L to O, Molecular Biology, Monoamine Oxidase B, Monoamine oxidase inhibitor, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, P
- {SNA} Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
- {SNA} Bioactive Small Mol
产品应用
- 具有明显的降压作用，单胺氧化酶(MAO-B)选择性抑制剂。
相关文献及参考
- Merck 14 ,7038
- Yang, W., et al., Inhibition Of Semicarbazide-sensitive Amine Oxidase Attenuates Myocardial Ischemia-reperfusion Injury In An In Vivo Rat Model. Leuk. Res. 88 , 302-6, (2011) 摘要
- Merck: 14,7038
- Merck: 14,7038 Beilstein: 12,II,548
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P301+P310
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S22 Do not breathe dust 不要吸入粉尘；
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1500 ug/kg/D TO
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 142 mg/kg TOXIC EFFECTS : Nutritional
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 107,1068,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 680 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature increase Behavioral - changes in motor activity (specific assay) Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 107,1068,1963
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : male 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 26,232,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 12 mg/kg SEX/DURATION : female 1-6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 27,147,1963
其他信息
- 有特异臭。易溶于水。水溶液不稳定，3.18％溶液为等渗溶液。
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