Homatropine (Bromide) 后马托品氢溴酸盐

CAS 51-56-9 MFCD00012676

化学结构图

51-56-9
SMILES: Br.CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2

化学属性

Mol. FormulaC16H22BrNO3
Mol. Weight356.25
Melting Point214-217 °C(lit.)
Solubility可溶
Boiling Point434.9 °C at 760 mmHg

别名和识别编码

Chemical NameHomatropine (Bromide)
CAS Number51-56-9
Synonym Homatropine (Bromide) {LY} Homatropine (Bromide) {} {LY} Homatropine (Bromide) {} {} {LY} Homatropine (Bromide) {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Homatropine (Bromide) {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00012676
EC Number200-105-3
Chemical Name Translation后马托品氢溴酸盐
Merck Number4730
Wiswesser Line NotationT56 A ANTJ A1 GOVYQR &EH
LabNetwork Molecule IDLN00188121
PubChem Substance ID6419941
InChIInChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14?,15?;
Canonical SMILESO=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.Br
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分类

  • Inhibitors
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards G - H, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards G - H, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Analytical Standards, EP Standards, EP Standards G - H, Pharmacopeia Metrological Institutes Standards, 分析/色谱
  • Aromatics

产品应用

  • Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the

相关文献及参考

  • [2]. Gilani, S.A. and L.B. Cobbin, Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Arch Int Pharmacodyn Ther, 1987. 290(1): p. 46-53.
  • [3]. Cramer, M.B., L.A. Cates, and D.E. Clarke, Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol, 1978. 30(5): p. 284-6.
  • Mattila, M.J. et al.: Ann. Med. Exp. Biol. Fen., 45, 412 (1967); Gambill, H. et al.: Arch. Ophthamol., 77, 740 (1967); Sund, R.B.: Med. Norsk Farmac. Sels., 33, 143 (1971);
  • [1]. Leung, E. and F. Mitchelson, Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol, 1982. 80(1): p. 11-7.
  • [1]. Leung, E. and F. Mitchelson, Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol, 1982. 80(1): p. 11-7.
  • [2]. Gi

安全信息

Hazard Codes T
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
UN Number 1544
RTECSYM5602000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 96,1,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 154 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,789,1982

Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed sto

其他信息

  • Sigma Aldrich:51-56-9(sigmaaldrich)
  • MOL 文件:51-56-9.mol
  • 氢溴酸后马托品价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 161700100 氢溴酸后马托品 DL-Homatropine hydrobromide 98.5-100.5% 10 GR 417元 2010/06/21 161700500 氢溴酸后马托品 DL-Homatropine hydrobromide 98.5-100.5% 50 GR 1350元
  • MSDS 信息:alpha-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide(51-56-9).msds
  • Acros Organics:DL-后马托品氢溴酸盐 DL-Homatropine hydrobromide, 98.5-100.5%(51-56-9)
  • TCI Shanghai:氢溴酸后马托品 Homatropine Hydrobromide,>;99.0%(T)(51-56-9)
  • 图谱信息:氢溴酸后马托品(51-56-9)红外图谱(IR1) 氢溴酸后马托品(51-56-9)核磁图( 13 CNMR) 氢溴酸后马托品(51-56-9)核磁图( 1 HNMR) 氢溴酸后马托品(51-56-9)红外图谱(IR2)

系列性分类

  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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