Betahistine Dihydrochloride 倍他司丁二盐酸盐

CAS 5579-84-0 MFCD00012813

化学结构图

5579-84-0
SMILES: CNCCc1ccccn1.Cl.Cl

化学属性

Mol. FormulaC₈H₁₄Cl₂N₂
Mol. Weight209.12
Melting Point148-155°C
Appearance 白色或类白色结晶或结晶性粉末。
Density0.967
Boiling Point

别名和识别编码

Chemical NameBetahistine Dihydrochloride
MDL NumberMFCD00012813
CAS Number5579-84-0
Synonym Aequamen Betahistin AL Betahistin Stada Betahistin ratiopharm Betahistin-ratiopharm Betahistine Betahistine Biphar Betahistine Dihydrobromide Betahistine Dihydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number226-966-5
PubChem Substance ID68643
Alfabeta NameMETHYLPYRIDINYLETHANAMINEHYDROCHLORIDE N22-----
Chemical Name Translation倍他司丁二盐酸盐
LabNetwork Molecule IDLN00178673
InChIInChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
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分类

  • {SNA} Analytical St
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
  • {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards,
  • {SNA} Building Blocks, C8, Chemical Synthesis,

相关文献及参考

  • [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.
  • [3]. Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.
  • [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
  • [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
  • [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism

安全信息

WGK Germany3
RTECSUT2969000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Warnings IRRITANT
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
Storage condition -20

其他信息

  • MOL 文件:5579-84-0.mol
  • 用途一:用于治疗内耳眩晕症（即美尼尔综合症）、脑动脉硬化、脑供血不足以及高血压引起的眩晕、呕吐与耳鸣。
  • 盐酸倍他司汀价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 167990010 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 1 GR 278元 2010/06/21 167990250 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 25 GR 2984元 2010/06/21 167990050 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 5 GR 755元
  • 组胺类扩张血管药物:盐酸倍他司汀又称抗眩宁、培他啶，为组胺H1受体激动剂，属组胺类扩张血管药物，具有扩张毛细血管，改善微循环作用，能增加脑血流量及内耳血流量，能松弛内耳毛细血管前括约肌，可消除内耳性眩晕、耳鸣和耳闭塞感。主要用于治疗梅尼埃病(一种特发性内耳疾病)，急、慢性缺血性脑血管疾病，也用于治疗脑动脉硬化、缺血性脑血管病、头部外伤或高血压所致直立性眩晕、头昏、耳鸣、耳聋、内耳眩晕症等，对多种原因的头痛均有缓解作用，对褥疮也有明显疗效。 倍他司汀盐酸盐对毛细血管的扩张作用与组胺相似，但不增加其通透性，能显著增加脑和内耳血流量，消除内淋巴水肿，直接抑制前庭神经核多触突Ⅰ型神经元产生的大量冲动，从而消除梅尼埃综合征的眩晕、耳鸣和耳闭等症状。该药也有轻微的抗凝血、抗血小板聚集、降低血液黏滞度和利尿作用。
  • Sigma Aldrich:5579-84-0(sigmaaldrich)
  • Acros Organics:N-甲基-2-吡啶乙胺二盐酸盐 2-(2-(Methylamino)ethyl)pyridine dihydrochloride, 99%(5579-84-0)
  • MSDS 信息:2-(2-(Methylamino)ethyl)pyridine dihydrochloride(5579-84-0).msds

系列性分类

  1. C6
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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