[(2-Chlorophenyl)Methylene]Malononitrile 邻氯亚苄基丙二腈

CAS 2698-41-1 MFCD00019784

化学结构图

2698-41-1
SMILES: N#CC(C#N)=Cc1ccccc1Cl

化学属性

Mol. FormulaC10H5ClN2
Mol. Weight188.61
Melting Point95 ºC
Boiling Point310-315 ºC
Solubility0.1-0.5 G/100 ML AT 16 ºC

别名和识别编码

Chemical Name[(2-Chlorophenyl)Methylene]Malononitrile
CAS Number2698-41-1
Synonym ######## ((2-Chlorophenyl)methylene)propanedinitrile (o-Chlorobenzal)malononitrile 2-Chlorobenzalmalononitrile 2-Chlorobenzylidene malononitrile 2-Chlorobmn CS Chlorobenzylidene malononitrile {hazard_com} NCI-C55118 Propanedinitrile, ((2-chlorophenyl)methylene) TL 238 USAF KF-11 beta,beta-Dicyano-o-chlorostyrene o-Chlorobenzylidene malonitrile o-Chlorobenzylidene malononitrile
MDL NumberMFCD00019784
EC Number220-278-9
Chemical Name Translation邻氯亚苄基丙二腈
Wiswesser Line NotationNCYCN&U1R BG
Beilstein Registry Number1866635
LabNetwork Molecule IDLN01263170
PubChem Substance ID17604
InChIInChI=1S/C10H5ClN2/c11-10-4-2-1-3-9(10)5-8(6-12)7-13/h1-5H
Canonical SMILESN#C/C(C#N)=C/C1=CC=CC=C1Cl
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • The defining component of tear gas (CS gas).

相关文献及参考

  • Brone, B., et al.: Toxicol. App. Pharmacol., 231, 150 (2008),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
  • P342+P311
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H301 Toxic if swallowed 吞食有毒
RTECSOO3675000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
UN Number 2647
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2326 mg/m3/10M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - hemorrha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   24,45,1973

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1802 mg/m3/10M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - hemorrhage
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   40,75,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - other changes
   Skin and Appendages - hair
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   40,75,1978

TYPE OF TEST            : LCLo - Lowest published lethal concentrati

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 18800 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 282,231,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 6 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-377,1990

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 19 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   63,314,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   49,15,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,91,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-377,1990

TYPE

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/m3/5M
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   37QLAZ "Current Approaches in Toxicology," Ballantyne, B., ed., Bristol, UK,
   John Wright & Sons, Ltd., 1977  Volume(issue)/page/year: -,79,1977

系列性分类


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