Hematoporphyrin Dihydrochloride 血卟啉二盐酸盐

CAS 17696-69-4 MFCD00013470

化学结构图

17696-69-4
SMILES: Cl.Cl.CC1C(C(C)O)=C2C=C3N=C(C=C4NC(=CC5=NC(=CC=1N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C)C(C(C)O)=C3C

化学属性

Mol. FormulaC34H38N4O6.2ClH
Mol. Weight671.68
TSCAYes

别名和识别编码

Chemical NameHematoporphyrin Dihydrochloride
MDL NumberMFCD00013470
Beilstein Registry Number78957
EC Number241-699-4
CAS Number17696-69-4
Synonym Acido 1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionico Hematoporphyrin IX dihydrochloride; 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid hydrochloride Haematoporphyrin dihydrochloride
Merck Number14,4636
Chemical Name Translation血卟啉二盐酸盐
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相关文献及参考

  • [2]. Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.
  • [3]. Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53.
  • [1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
  • [1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
  • [2]. Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.
  • [3]. Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;

安全信息

WGK Germany2
RTECSTS5505000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 169 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 278 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,145,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(iss

系列性分类

  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Porphyrins
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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