Aminophylline 氨茶碱

CAS 317-34-0 MFCD00013221

化学结构图

317-34-0
SMILES: Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN

化学属性

Mol. FormulaC16H24N10O4
Mol. Weight420
Appearance 白色或淡黄色颗粒或粉末。熔点269-274℃。易溶于水，不溶于乙醇或乙醚。露置空气中逐渐吸收二氧化碳气体而分解或茶碱。微有近臭，味苦。 powder
SolubilityH2O: 3.7 mg/mL solutions should be freshly prepared.
Melting Point269-270°C
Density1.514

别名和识别编码

Chemical NameAminophylline
Synonym Aminophylline dihydrochloride hyderate 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine( aminocadol 茶碱胺 carena aminophyllin 氨茶碱 (Theophylline)2 · Ethylenediamine 茶碱乙烯二胺 (Theophylline)2 · Ethylenediamine 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemi(ethylenediamine) complex Theophylline hemiethylenediamine complex 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dionecompd.with1,2-ethanediamine(2 cardophyllin 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compdwith1,2-ethanediamine(2 cariomin aminodur cardiomin 无水氨茶硷 Amminofillina cardiofilina THEOPHYLLINE ETHYLENEDIAMINE THEOPHYLLINE COMPOUND WITH ETHYLENEDIAMINE AMINOPHYLLINE cardophylin Theophylline hemi(ethylenediamine) complex 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine 乙二胺茶碱 ammophyllin 1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮-1,2-乙二胺盐 aminofilina 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemiethylenediamine complex aminocardol 氨茶碱，水合
CAS Number317-34-0
PubChem Substance ID9433
EC Number206-264-5
MDL NumberMFCD00013221
Chemical Name Translation氨茶碱
Merck Number465
Reaxys-RN5783720
LabNetwork Molecule IDLN01740182
InChIInChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
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分类

  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors
  • {SNA} A-AM, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 细胞生物学
  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology,

产品应用

  • 非选择性磷酸酯酶抑制剂（phosphodiesterase ，PDE），抗癫痫药。

相关文献及参考

  • [2]. E Tai, et al. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22(6):543-9.
  • [3]. Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.
  • Chanda, et al., Antiepileptic drugs and methylxanthines: clinical significance. Pol. J. Pharmacol. 50 , 80-82, (1998) 摘要
  • Merck: 14,465
  • Thakker, et al. Analytical Profiles of Drug Substances 2nd ed.,, (1982) 2 , 1-44
  • [1]. Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/keta
  • [1]. Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. ur J Pharmacol. 2010 Feb 10;627(1-3):269-75.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 Xn Xn,C
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSXH5600000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P333+P313+P362+P364
  • P308+P311
  • P308+P313
Signal word Danger
Packing GroupIII
Hazard Class6.1
Storage condition -20°C <0°C 储存温度： -20°C
UN Number 2811 UN 2811 6.1/PG 3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R42/43
  • R22 Harmful if swallowed 吞咽有害

其他信息

  • 上游原料:茶碱 --> 混合机
  • 方法一:本品为茶碱与乙二胺的复盐。将茶碱投入混合机，搅拌冷却，用压缩空气喷入新蒸馏过的乙二胺和蒸馏水的混和液，喷毕，继续搅拌10分钟，得氨茶碱。
  • 用途一:主要用于支气管哮喘和哮喘型慢性支气管炎，也可用于急性心功能不全、心脏性哮喘及胆绞痛等
  • 易溶于水，不溶于乙醇或乙醚,露置空气中逐渐吸收二氧化碳气体而分解或茶碱,微有近臭，味苦。
  • 用途二:本品作用、用途与茶碱相同。分子中乙二胺在存在增强了扩张支气管和冠状血管作用。
  • MSDS 信息:Theophylline-ethylenediamine-addition compound (2:1)(317-34-0).msds
  • F:10-23
  • color:white to off-white
  • 用途三:非选择性磷酸酯酶抑制剂（phosphodiesterase ，PDE），抗癫痫药。
  • MOL 文件:317-34-0.mol
  • Sigma Aldrich:317-34-0(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Phosphodiesterase Inhibitors - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Phosphodiesterase Inhibitors - Cyclic Nucleotide Metabolism
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)
  1. Medical Research Areas
  2. Metabolism
  3. Phosphodiesterase (PDE)  (磷酸二酯酶)

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