• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Alkaloid, Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification
• {SNA} Alkaloid, Anti-Proliferative Agents,
• {SNA} Alkaloid, Anti-Proliferative Agents, Antitumor Agents, B, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Membrane Protein Biology Tools, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Nutrition Research, Phytochemicals by Chemical Classification, Proteins and Derivatives
• {SNA} Alkaloid,

产品应用

• 对细菌（主要痢疾、大肠杆菌，金葡球菌）具有微弱的抑制作用，并使细菌体上表面的菌毛数量减少，使细菌不易附着在人体细胞上，能使胃及十二指肠的消化道溃疡减轻。主要用于治疗胃肠炎、细菌性痢疾等肠道感染、腹泻。

相关文献及参考

• Zhang, X., et al., Degradation Of MDM2 By The Interaction Between Berberine And DAXX Leads To Potent Apoptosis In MDM2-Overexpressing Cancer Cells. Cancer Res. 70 , 9895-904, (2010) 摘要
• Berlin, G. and Enerback, L. Agents and Actions 14 , 401, (1984)
• Dimlich, R.V.W., et al. Stain Technol. 55 , 217, (1980)
• Lin, H.L., et al. Cancer 85 , 1937-1942, (1999) 摘要
• Schumacher, M.A., et al. Science 294 , 2158, (2001) 摘要
• Beil. 27 ,II,567

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 104,253,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 25,335,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >29586 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,654,1974

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,243,1993

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 22 umol/L
REFERENCE :
   IJBBBQ Indian Journal of Biochemistry and Biophysics.  (Publications &
   Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8- 
     1971-  Volume(issue)/page/year: 18,245,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,243,1993

其他信息

• TCI Shanghai:氯化黄连素水合物 Berberi
• 方法一:以黄樟油素为原料，在减压下异构化得异黄樟油素，经氧化生成胡椒醛。胡椒醛与硝基甲烷缩合得β-硝基-3,4-二氧亚甲基苯乙烯，进一步还原得胡椒乙胺[1484-85-1]：胡椒乙胺与邻藜芦醛缩合，再经催化氢化、成盐、环合，碱化得小檗碱。继续用盐酸成盐即得黄连素。1.缩合、催化氢化、成盐将无水乙醇与邻藜芦醛混合，在搅拌下再加胡椒乙胺，稍加热使全部溶解。搅拌10min以上使缩合反应完全。另将镍催化剂与无水乙醇混和后与缩合物一起投入高压釜。先通氮置换空气，再通入氢气，控制压力接近4MPa、温度80-90℃，将氢化反应进行到不再吸氢，并继续保温、保压通氢1h为止。冷至30℃，降压至2MPa，静置，使镍催化剂沉降，再利用高压釜余压将反应液压出。压滤除去催化剂（浸入乙醇，供下批套用），滤液在搅拌下于50℃用盐酸乙醇酸化至pH3-4，冷却至5℃，保持4h使结晶。过滤，用少量乙醇洗涤，干燥即得N-2,3-二甲氧苄基胡椒乙胺盐酸盐。收率84%。2.环合、碱化、成盐依次将冰醋酸、乙酐、硫酸铜及氯化钠投入反应锅中，搅拌升温至65-70℃，缓缓加入乙二醛，升温至回流20min，冷却至90℃，加N-2,3-二甲氧苄基胡椒乙胺盐酸盐，升温至112-114℃反应4h。减压回收乙酸至投料量的70-80%后，加水搅匀，过滤。滤饼用热水洗涤，滤干，即得小檗三盐酸盐粗品。粗品先用石灰乳碱化得pH8-8.5，过滤得到的小檗碱氢氧化物滤液和洗液，以稀盐酸调pH1-2，过滤，滤饼溶于热水，加活性炭脱色，过滤，用稀盐酸调pH1-2，冷却，过滤，水洗，干燥，即得黄连素。小檗碱存在于小檗科等四个科十个属的许多植物中，用提取法生产小檗碱的工艺过程是：取三颗针或十根地下根洗静，切成薄片，晒干，粉碎，加0.5%硫酸溶液加热浸泡3-4次，每次24h。第3、4次浸出液套用浸泡下一批生药。第1、2次浸出液过滤，滤液加氯化钠饱和，放置，把结晶分离出来即为粗品。粗品用酸碱法精制得成品。每百公斤生药可得成品0.5kg。
• 可燃性危险特性:燃烧产生有毒氮氧化物烟雾;
• 上游原料:硝基甲烷 --> 乙二醛 --> 胡椒醛 --> 黄樟素 --> 2,3-二甲氧基苯甲醛 --> 异黄樟素 --> 盐酸小檗碱
• Sigma Aldrich:141433-60-5(sigmaaldrich)
• 毒性分级:高毒
• 用途二:黄连素为抗菌药物，是《国家基本药物目录》，选列的品种，该品对溶血性链球菌，金黄色葡萄球菌，淋球菌和弗氏、志贺氏痢疾杆菌等均有抗菌作用，并有增强白血球吞噬作用，
• F:3-10
• Alfa Aesar:<17% Berberine chloride hydrate, 97%, water <17%(141433-60-5)" href="http://www.alfa.com/zh/GP100w.pgm?DSSTK=L03807&CAS;=141433-60-5">氯化黄连素,97%,水<17% Berberine chloride hydrate, 97%, water <17%(141433-60-5)
• 储运特性:低温通风低干燥; 因需求限量存储, 以防过量, 皮肤吸附中毒
• 盐酸小檗碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 B0450 氯化黄连素水合物 Berberine Chloride Hydrate 25G 481元 2010/05/25 L03807 氯化黄连素,97%, 水 <17% Berberine chloride hydrate, 97%, water <17% 5g 246元 2010/05/25 L03807 氯化黄连素,97%, 水 <17% Berberine chloride hydrate, 97%, water <17% 25g 825元
• 急性毒性:口服-小鼠 LD50: 329 毫克/公斤; 皮下-小鼠 LD50: 18 毫克/公斤
• EPA化学物质信息:Benzo[g]-1,3-benzodioxolo[ 5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride(633-65-8)