Benzamide,N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-,monohydrochloride Sematilide 单盐酸盐 一水合物

CAS 101526-62-9 MFCD01667315

化学结构图

101526-62-9
SMILES: Cl.CS(=O)(=O)NC1C=CC(=CC=1)C(=O)NCCN(CC)CC

化学属性

Mol. FormulaC14H23N3O3S· HCl · H2O
Mol. Weight367.89

别名和识别编码

Chemical NameSematilide monohydrochloride monohydrate
Synonym CK 1752A CK-1752A N-[2-(Diethylamino)ethyl]-4'-[(methylsulfonyl)amino]benzamide 单盐酸盐 一水合物 N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide Sematilide 单盐酸盐 一水合物 CK-1752A N-[2-(Diethylamino)ethyl]-4'-[(methylsulfonyl)amino]benzamide 单盐酸盐 一水合物
CAS Number101526-62-9 (free base)
Chemical Name TranslationSematilide 单盐酸盐 一水合物
MDL NumberMFCD11041004
PubChem Substance ID329824420
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators, S, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

安全信息

RTECSCV4203840 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,182,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,182,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   10,1

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

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