Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-

CAS 13045-94-8 MFCD01674289

化学结构图

13045-94-8
SMILES: NC(CC1C=CC(=CC=1)N(CCCl)CCCl)C(O)=O

化学属性

Mol. FormulaC13H18Cl2N2O2
Mol. Weight305.23

别名和识别编码

Chemical NameAlanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-
Wiswesser Line NotationQVYZ1R DN2G2G -D
Synonym D-Sarcolysine D-Phenylalanine, 4-(bis(2-chloroethyl)amino)- 3026 C.B. NSC-35051 p-Di-(2-chloroethyl)-amino-D-phenylalanine (+)-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine p-Di(2-chloroethyl)amino-d-phenylalanine D-Phenylalanine mustard Medphalan D-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine CB-3026 4-(Bis(2-chloroethyl)amino)-D-phenylalanine Medfalan
CAS Number13045-94-8
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   10,363,1956

RTECSAY3370000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 113 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 18,760,1966

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   JOGNAU Journal of Genetics.  (Belghoria, India)  V.1-63, 1910-77.
   Discontinued.  Volume(issue)/page/year: 54,146,1956

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10700 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,195,1970

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