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分类

• Antagonists, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chloride Channel Modulators, GABA and Glycine Receptor Modulators, GABAergics, Ion Channels, Ligand-Gated Ion Channels, Monovalent Ion Channels, Neuroscience,

相关文献及参考

• Behrends, J.C., Modulation by bicuculline and penicillin of the block by t-butyl-bicyclo-phosphorothionate (TBPS) of GABA(A)-receptor mediated Cl − -current responses in rat striatal neurones. Br. J. Pharmacol. 129 , 402, (2000) 摘要
• Jursky, F., et al., Identification of amino acid residues of GABA(A) receptor subunits contributing to the formation and affinity of the tert-butylbicyclophosphorothionate binding site. J. Neurochem. 74 , 1310-1316, (2000) 摘要
• Poulter, M.O., Evidence that GABA A receptor subunit mRNA expression during development is regulated by GABA A receptor stimulation. J. Neurochem. 68 , 631, (1997) 摘要
• Tehrani, M.H, et al., Interaction of t-butylbicyclo-phosphorothionate with γ-aminobutyric acid-gated chloride channels in cultured cerebral neurons. J. Neurochem. 46 , 1542-1548, (1986) 摘要
• Casida, et al., Bicycloorthocarboxylate convulsants. Potent GABA-A receptor antagonists. Mol. Pharmacol. 28 , 246, (1985) 摘要

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   47,287,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 38,1734,1990