Sodium (5R,6S)-6-((R)-1-Hydroxyethyl)-7-Oxo-3-((R)-Tetrahydrofuran-2-Yl)-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate (5R,6S)-6-((R)-1-羟乙基)-7-氧代-3-((R)-四氢呋喃-2-基)-4-硫杂-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸钠
CAS 122547-49-3 MFCD01682061
化学结构图
SMILES: [Na+].C[C@@H](O)[C@@H]1[C@H]2SC([C@H]3CCCO3)=C(C([O-])=O)N2C1=O
化学属性
| Mol. Formula | C12H14NNaO5S · xH2O |
|---|---|
| Mol. Weight | 307.30 (anhydrous basis) |
别名和识别编码
| Chemical Name | Sodium (5R,6S)-6-((R)-1-Hydroxyethyl)-7-Oxo-3-((R)-Tetrahydrofuran-2-Yl)-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate |
|---|---|
| Synonym | (5R,6S)-6-(1(R)-Hydroxyethyl)-2-(2(R)-tetrahydrofuryl)penem-3-carboxylic (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-hydroxyethylpenem-3-carboxylate sodium salt (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-hydroxyethylpenem-3-carboxylate sodium salt ALP 201 Farom Fropenem Furopenem SUN 5555 SY 5555 Wy 49605 ALP 201 Farom Fropenem Fropenum sodium Furopenem SUN 5555 SY 5555 Wy 49605 |
| CAS Number | 122547-49-3 (anhydrous) |
| MDL Number | MFCD17215925 |
| PubChem Substance ID | 329799769 |
| Chemical Name Translation | (5R,6S)-6-((R)-1-羟乙基)-7-氧代-3-((R)-四氢呋喃-2-基)-4-硫杂-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸钠 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Daiichi-Sankyo, F, Fluorination Ready Pharma-Developed Compounds, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,525,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - incontinence REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,525,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,525,1993
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECI
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE : 2600 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 47,139,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 6720 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 42(Suppl 1),161,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30240 mg/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Reproductive - Maternal Effects - other effects
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
42(Suppl 1),161,1994
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