2，3-Bis(4-Hydroxyphenyl)Propionitrile 2,3-双(4-羟苯基)丙腈

CAS 1428-67-7 MFCD01695412

化学结构图

1428-67-7
SMILES: N#C[C@H](Cc1ccc(O)cc1)c1ccc(O)cc1

化学属性

Mol. FormulaC15H13NO2
Mol. Weight239
Melting Point200.0 to 204.0 deg-C

别名和识别编码

Chemical Name2，3-Bis(4-Hydroxyphenyl)Propionitrile
Synonym 2,3-Bis(4-hydroxyphenyl)propionitrile 2,3-Bis(p-hydroxyphenyl)propionitrile DPN DPN Diarylpropionitrile SC-4473 Diarylpropionitrile SC-4473
CAS Number1428-67-7
MDL NumberMFCD01695412
Chemical Name Translation2,3-双(4-羟苯基)丙腈
Reaxys-RN3337109
PubChem Substance ID102614
InChIKeyGHZHWDWADLAOIQ-UHFFFAOYSA-N
Wiswesser Line NotationQR DYCN&1R DQ
Beilstein Registry Number3337109
LabNetwork Molecule IDLN00206579
InChIInChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
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分类

  • {SNA} B, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Estrogen, Hormones, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen,

相关文献及参考

  • Lewis, D.K., et al., Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. J. Neuroimmunol. , (2008)
  • Meltser, I., et al., Estrogen receptor β protects against acoustic trauma in mice. J. Clin. Invest. , (2008)
  • Walf, A.A., et al., Estradiol or diarylpropionitrile administration to wild type, but not estrogen receptor β knockout, mice enhances performance in the object recognition and object placement tasks. Neurobiol. Learn. Mem. , (2008)

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P302+P350
  • P337+P313
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P305+P351+P338
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P304+P340+P312
Signal word Warning
Hazard statements
  • H302+H312+H332
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xi,N
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R50 Very toxic to aquatic organisms 对水生生物极毒
RTECSUG0900000
Storage condition <0°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 112,176,1954

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Estrogen - Steroid Hormones

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