Phenmetrazine hydrochloride

CAS 1707-14-8 MFCD01707148

化学结构图

1707-14-8
SMILES: CC1NCCOC1c1ccccc1.Cl

化学属性

Mol. Weight213.73
Mol. FormulaC11H15NO.ClH

别名和识别编码

CAS Number1707-14-8
Chemical NameMorpholine, 3-methyl-2-phenyl-, hydrochloride
Synonym 2-Phenyl-3-methyltetrahydro-1,4-oxazine hydrochloride 3-Methyl-2-phenylmorpholine 3-Methyl-2-phenylmorpholine hydrochloride 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine hydrochloride A 66 hydrochloride Defenmetrazin Fenmetrazin Hydrochloride, Phenmetrazine Marsin Neo-zine Oxazimedrine Phenmetraline Phenmetrazine Phenmetrazine Hydrochloride Phenmetrazine hydrochloride Preludin Preludin hydrochloride Probese-P hydrochloride Psychamine A 66 hydrochloride USAF GE-1
Wiswesser Line NotationT6M DOTJ B1 CR &GH
PubChem Substance ID92159
InChIInChI=1S/C11H15NO.ClH/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10;/h2-6,9,11-12H,7-8H2,1H3;1H
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分类

  • Amines
  • Aromatics
  • Heterocycles

产品应用

  • Anorexic.

相关文献及参考

  • Klosa, et al.: J. Prakt. Chem., 21, 12 (1963),

安全信息

Restrict {} 精神药品 精麻类化学品
RTECSQE6650000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,589,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,286,1972

TYPE OF TEST

{hazard_

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 5580

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Skin and Appendages - hair
REFERENCE :
   APSXAS Acta Pharmaceutica Suecica.  (Apotekarsocieteten-Farmacevtiska
   Foereningen, Box 1136, S-111, 81 Stockholm, Sweden)  V.1-    1964-
   Volume(issue)/page/year: 4,37,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 84 mg/kg
SEX/DURATION            : female 28-84 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - respiratory system
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,1327,1962

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P310
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类


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