N-BENZYLADRIAMYCIN-14-VALERATE

CAS 98983-21-2 MFCD01709238

化学结构图

98983-21-2
SMILES: C[C@@H]1O[C@H](C[C@H](NCC2C=CC=CC=2)[C@H]1O)O[C@H]1C[C@H](CC2C1=C(O)C1=C(C(=O)C3C=CC=C(OC)C=3C1=O)C=2O)OC(=O)COC(=O)CCCC

化学属性

Mol. FormulaC39H43NO12
Mol. Weight717.76

别名和识别编码

Chemical NameAD 198
Synonym AD 198 N-Benzyladriamycin-14-valerate
CAS Number98983-21-2
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分类

  • A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology

相关文献及参考

  • Lothstein, L., et al. , N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx. Anti-Cancer Drugs 17 , 495-502, (2006)
  • Bilyeu, J. D., et al. , Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines. Mol. Pharmacol. 65 , 1038-1047, (2004) 摘要

安全信息

RTECSSA3697000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 3 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   37,1763,1988

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Activators - Serine/Threonine Kinase Biology
  7. Protein Kinase C (PKC) - Serine/Threonine Kinase Activators

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