N-Ethyl-N-(2-Hydroxyethyl)Nitrosamine N-乙基-N-(2-羟乙基)亚硝胺

CAS 13147-25-6 MFCD01727871

化学结构图

13147-25-6
SMILES: CCN(CCO)N=O

化学属性

Mol. FormulaC4H10N2O2
Mol. Weight118.14
Refractive index1.4710 to 1.4750
Boiling Point103°C/3mmHg(lit.)

别名和识别编码

Chemical NameN-Ethyl-N-(2-Hydroxyethyl)Nitrosamine
Synonym N-Nitroso-N-ethyl-N-(2-hydroxyethyl)amine EENA Ethanol, 2-(ethylnitrosoamino) EHEN 2-(Ethylnitrosamino)ethanol N-Nitrosoaethylaethanolamin Ethanol, 2-ethylnitrosoamino N-Nitrosoethylethanolamine Ethyl-2-hydroxyethylnitrosamine N-Nitrosoethyl-2-hydroxyethylamine Aethyl-aethanol-nitrosoamin N-Ethyl-N-hydroxyethylnitrosamine
MDL NumberMFCD01727871
CAS Number13147-25-6
Reaxys-RN2073939
PubChem Substance ID87569818
Chemical Name TranslationN-乙基-N-(2-羟乙基)亚硝胺
Wiswesser Line NotationQ2N2&NO
Beilstein Registry Number2073939
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分类

  • {uni_hamburg} no charge; alcohol; 1fragment

相关文献及参考

  • Short: IV/20C Title: Vapor Pressure and Antoine Coefficients for Nitrogen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20C Year: 2001 Keyword: organic compounds; vapor pressure ISBN: 3-540-41060-0 ISBN: 978-3-540-41060-7 Internet Resource: DOI:10.1007/b88812 RefComment: VII, 197 pages

安全信息

RTECSKL0350000
Storage condition 0-10 0-10°C
Signal word
Hazard statements
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 7,1313,1986

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg/2W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NAIZAM Nara Igaku Zasshi.  Journal of the Nara Medical Association.  (Nara
   Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 31,361,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1680 mg/kg/14D-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Liver - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg/1W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 70,477,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   50,100,1963

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Kidney
DOSE/DURATION           : 18 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,41,1996

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,1,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Kidney
DOSE/DURATION           : 18 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,41,1996

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 390,51,1997

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 39 umol/kg
REFERENCE :
   JCROD7 Journal of Cancer Research and Clinical Oncology.  (Springer-Verlag
   New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.93-
   1979-  Volume(issue)/page/year: 111,20,1986

GHS Symbol

系列性分类

  1. Functional Group 官能团索引
  2. nitroso compound

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