2-Chlorooxirane

CAS 7763-77-1 MFCD01728892

化学结构图

7763-77-1
SMILES: ClC1CO1

化学属性

Mol. FormulaC2H3ClO
Mol. Weight78.50

别名和识别编码

Chemical NameChloroethylene oxide
InChIKeyWBNCHVFLFSFIGK-UHFFFAOYSA-N
Wiswesser Line NotationT30TJ BG
Synonym 2-chloroethylene oxide Chloroethylene oxide Chlorooxirane Monochloroethylene oxide Oxirane, chloro- chloroethylene oxide chlorooxirane
CAS Number7763-77-1
Beilstein Registry Number0102403
PubChem Substance ID24472
InChIInChI=1S/C2H3ClO/c3-2-1-4-2/h2H,1H2
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg/42W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,352,1980

RTECSKH7705000
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 6 umol/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,639,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   IAPUDO IARC Publications.  (WHO Publications Centre USA, 49 Sheridan Ave.,
   Albany, NY 12210) No.27-    1979-  Volume(issue)/page/year: 70,345,1986

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 40 umol/L
REFERENCE :
   COINAV Coll

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 5 gm/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   17,239,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 500 umol/L
REFERENCE :
   COINAV Colloques Internationaux du Centre National de la Recherche
   Scientifique.  (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA
   02018)  V.1-    1946-  Volume(issue)/page/year: 256,315,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 260 mmol/L
REFERENCE :
   37ATAD "Prevention and Detection of Cancer, Proceedings of the 3rd
   International Symposium on Detection and Prevention of Cancer," New York,
   Marcel Dekker, 1977  Volume(issue)/page/year: -,155,1977

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