Bleomycin A2

CAS 11116-31-7 MFCD01745092

化学结构图

11116-31-7
SMILES: CC1C(N)=NC(=NC=1C(=O)N[C@@H]([C@@H](O[C@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)C1=CNC=N1)C(=O)N[C@H](C)[C@@H](O)[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC1=NC(=CS1)C1=NC(=CS1)C(=O)NCCC[S+](C)C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O

化学属性

Mol. FormulaC55H84N17O21S3
Mol. Weight1415.74

别名和识别编码

Chemical NameBleomycin A2
Synonym Zhengguangmycin A2
CAS Number11116-31-7
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安全信息

RTECSEC5988500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspended 1966-78.  Volume(issue)/page/year:
   14,83,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2143 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosing alveolitis
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,1267,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspended 1966-78.  Volume(issue)/page/year:
   14,83,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Lung
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Vol

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1667 mg/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

{hazard_c

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 8 mg/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 22,446,1969

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1100 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   521,520,1978

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 5 umol/L
REFERENCE :
   CRTOEC Chemical Research in Toxicology.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC
   20037)  V.1-    1988-  Volume(issue)/page/year: 1,25,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Ascites tumor
DOSE/DURATION           : 13 mg/L
REFERENCE :
   PLCHB4 Physiological Chemistry and Physics.  (Washington, DC)  V.1-14,
   1969-82.  Volume(issue)/page/year: 7,177,1975

TYPE OF TEST            : DNA inhibition
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系列性分类

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