Propanamide,N-(1-(2-hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-N-phenyl-

CAS 78995-14-9 MFCD01749027

化学结构图

78995-14-9
SMILES: CCC(=O)N(C1CCN(CC1C)C(C)C(O)C1C=CC=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC23H30N2O2
Mol. Weight366.55

别名和识别编码

Chemical NamePropanamide,N-(1-(2-hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-N-phenyl-
CAS Number78995-14-9
Synonym F 7302 N-(1-(2-Hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-N-phenylpropanamide Ohmefentanyl N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A prodrug

相关文献及参考

  • Suzuki, T., et al.: Brain Res., 602, 45 (1993),
  • Wang, Z., et al.: J. Med. Chem., 38, 3652 (1995),
  • Nestler, E., et al.: Science, 292, 2266 (2001),

安全信息

RTECSTX1467000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 7300 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   5,153,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   5,153,1984

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