LG100268 LG100268
CAS 153559-76-3 MFCD01758574
化学结构图
SMILES: CC1C=C2C(=CC=1C1(CC1)C1C=CC(=CN=1)C(O)=O)C(C)(C)CCC2(C)C
化学属性
| Mol. Formula | C24H29NO2 |
|---|---|
| Mol. Weight | 363.49 |
别名和识别编码
| Chemical Name | LG100268 |
|---|---|
| CAS Number | 153559-76-3 |
| Synonym | 2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid AGN 192620 ALRT 268. CD 3127 LG268 LGD 100268 LGD 1268 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-Pyridinecarboxylic Acid AGN 192620 ALRT 268 CD 3127 LG 100268 LG 268 LG100268 LGD 100268 LGD 1268 |
| MDL Number | MFCD01758574 |
| PubChem Substance ID | 329825287 |
| Chemical Name Translation | LG100268 |
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分类
- Pharmaceuticals
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
- Retinoids,
- Intermediates & Fine Chemicals
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, L, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
相关文献及参考
- [2]. D S Lala, et al. Activation of Specific RXR Heterodimers by an Antagonist of RXR Homodimers.Nature. 1996 Oct 3;383(6599):450-3.
- [3]. Martine Cao,et al.The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. Cancer Prev Res (Phila). 2016 Jan;9(1):105-14.
- Clyne, C., et al.: J. Biol. Chem., 277, 20591 (2002),
- Falender, A., et al.: Endocrinology, 144, 3598 (2003),
- Santen, R., et al.: J. Clin. Endocrinol. Metab., 87, 3007 (2002),
- [1]. M F Boehm, et al. Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells. J Med Chem
- [1]. M F Boehm, et al. Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells. J Med Chem
- [2]. D S Lala, et al. Activation of Specific RXR Heterodimers by an Antagonist of RXR Homodimers.Nature. 1996 Oct 3;383(6599):450-3.
- [3]. Martine Cao,et al.The
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