(S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid (S)-3-(3,4-二羟基苯基)-2-肼基-2-甲基丙酸
CAS 28860-95-9 MFCD00069231
化学结构图
SMILES: CC(CC1=CC(O)=C(O)C=C1)(NN)C(O)=O
化学属性
| Mol. Formula | C10H14N2O4 |
|---|---|
| Mol. Weight | 226 |
别名和识别编码
| Chemical Name | (S)-3-(3,4-Dihydroxyphenyl)-2-Hydrazinyl-2-Methylpropanoic Acid |
|---|---|
| Synonym | (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (S)- Carbidopa Hydrazino-alpha-methyldopa L-alpha-Methyldopahydrazine MK 486 N-Aminomethyldopa S-(-)-Carbidopa S-(-)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid alpha-Methyldopahydrazine |
| MDL Number | MFCD00069231 |
| PubChem Substance ID | 24892402 |
| CAS Number | 28860-95-9 |
| EC Number | 249-271-9 |
| Chemical Name Translation | (S)-3-(3,4-二羟基苯基)-2-肼基-2-甲基丙酸 |
| Wiswesser Line Notation | ZMX1&VQ1R CQ DQ |
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资金保障
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分类
- {SNA} A to C, Aromatic L-amino acid decarboxylase inhibitor, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, 生化试剂, 酶、抑制剂和底物
- {SA} Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, L-Aromatic Amino Acid Decarboxylase,
相关文献及参考
- 1. Gilbert, J.A., et al., Hydrogen peroxide degradation and selective carbidopa-induced cytotoxicity against human tumor lines Biochem. Pharmacol. 69 , 1159-1166, (2005) 摘要
- Deleu, D., et al. Naunyn Schmiedebergs Arch. Pharmacol. 348 , 576, (1993) 摘要
- Kaakkola, S., et al. J. Neurochem. 60 , 137, (1993) 摘要
- Merck 14 ,1797
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 468 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,1127,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2804 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,1127,1980
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 49,415,1985
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2880 mg/kg SEX/DURATION : female 90 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2100 mg/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 38,251,1976
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