MMP INHIBITOR I

CAS 124168-73-6 MFCD00237459

化学结构图

124168-73-6
SMILES: CC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C1=CC=C(N)C=C1)C(=O)N[C@H](C)C(=O)NO

化学属性

Mol. FormulaC23H34N6O6
Mol. Weight490.55

别名和识别编码

Chemical Name4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
Synonym FN-439
MDL NumberMFCD00237459
PubChem Substance ID24890847
CAS Number124168-73-6
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分类

  • {SNA} Application Index, Cell Signaling Enzymes, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Extracellular Matrix Peptides (ECM), Matrix Metalloproteinase Inhibitors and Substrates, Matrix Metalloproteinases Products, Metalloproteinase Inhibitors, Other MMP Inhibitors, Peptides and Proteins, Peptides for Cell Biology, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • A-AM, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Enzymes, Inhibitors, and Substrates,

相关文献及参考

  • Odake, S., et al., Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids. Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991) 摘要
  • Odake, S., et al., Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids. Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994) 摘要
  • Anan, H., et al., Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J. Endod. 22 , 668-673, (1996) 摘要
  • Kigasawa, K., et al., Inhibition of corneal ulceration by tetrapeptidyl hydroxamic acid. Jpn. J. Ophthalmol. 39 , 35-42, (1995) 摘要
  • Garmer, D.R., et al., Modeling of inhibitor-metalloenzyme interactions and selectivity using molecular mechanics grounded in quantum chemistry. Proteins 31 , 42-60, (1998)

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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