Adiphenine HCl 阿地芬宁盐酸盐

CAS 50-42-0 MFCD00050508

化学结构图

50-42-0
SMILES: CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1.Cl

化学属性

Mol. FormulaC20H26ClNO2
Mol. Weight348
SolubilityDMSO 30 mg/mL Water 70 mg/mL Ethanol 18 mg/mL
Melting Point115.0 to 119.0 deg-C

别名和识别编码

Chemical NameAdiphenine HCl
MDL NumberMFCD00050508
CAS Number50-42-0
Synonym Adiphen hydrochloride 解痉素 盐酸盐 Adifenin hydrochloride 阿地芬宁盐酸盐;解痉素盐酸盐;2-(二乙氨基)二苯乙酸乙酯盐酸盐;2-(二乙氨基)二苯基乙酸乙酯盐酸盐;二苯乙酸 2-(二乙胺基)乙酯 Diphenylacetic acid 2-(diethylamino)ethyl ester hydrochloride 二苯乙酸 2-(二乙胺基)乙酯 阿地芬宁盐酸盐;解痉素盐酸盐;2-(二乙氨基)二苯乙酸乙酯盐酸盐;2-(二乙氨基)二苯基乙酸乙酯盐酸盐;二苯乙酸 2-(二乙胺基)乙酯;盐酸阿地芬宁 Benzeneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl-ester, Adiphenine hydrochloride
PubChem Substance ID5763
EC Number200-036-9
Chemical Name Translation阿地芬宁盐酸盐
Reaxys-RN3919592
Merck Number161
Wiswesser Line Notation2N2&2OVYR&R &GH
LabNetwork Molecule IDLN00194909
InChIInChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,19H,3-4,15-16H2,1-2H3;1H
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分类

  • {SNA} Additional Drugs, Additional Standards, Analytical Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SNA} A, AA to AL, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
  • {SA} A, AA to AL, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds

安全信息

RTECSAH2625000
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P302+P352+P312+P362+P364
  • P304+P312
  • P304+P340
  • P304+P340+P312
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 储存温度-20°C
TYPE OF TEST            : LDL

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BDCBAD Berichte der Deutschen Chemischen Gesellschaft.  Abteilung B:
   Abhandlungen.  (Heidelberg, Fed. Rep. Ger.)  V.62-77, 1929-45.  For
   publisher information, see CHBEAM.  Volume(issue)/page/year: 72,1551,1939

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
   Cardiac - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 59,365,1937

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 96,151,1949

{hazar

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB

其他信息

  • 解痉素 盐酸盐
  • Adiphenine HCl 是一种烟碱受体抑制剂,IC50为15 μM,用作解痉药。

系列性分类


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