2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺
CAS 24526-64-5 MFCD00242716
化学结构图
SMILES: CN1CC2=C(N)C=CC=C2C(C1)C1C=CC=CC=1
化学属性
| Mol. Formula | C16H18N2 |
|---|---|
| Mol. Weight | 238.36 |
别名和识别编码
| Chemical Name | 2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine |
|---|---|
| Wiswesser Line Notation | T66 CNT&J C1 ER& JZ |
| Synonym | 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl- Nomifensin Nomifensine 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline |
| CAS Number | 24526-64-5 |
| Chemical Name Translation | 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺 |
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安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 264 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - aggression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 7 mg/kg/7D-I TOXIC EFFECTS : Blood - hemorrhage Blood - thrombocytopenia REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXP
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 4 mg/kg SEX/DURATION : lactating female 1 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987
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