Phentolamine
CAS 50-60-2 MFCD00242985
化学结构图
SMILES: Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1
化学属性
| Mol. Formula | C₁₇H₁₉N₃O |
|---|---|
| Mol. Weight | 281.35 |
别名和识别编码
| Chemical Name | Phentolamine |
|---|---|
| EC Number | 200-053-1 |
| Synonym | 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)- 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)-2-imidazolin 2-((n-(m-hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline 2-(m-hydroxy-n-p-tolylanilinomethyl)-2-imidazoline 2-(n-(m-hydroxyphenyl)-p-toluidinomethyl)imidazoline 2-(n’-p-tolyl-n’-m-hydroxyphenylaminomethyl)-2-imidazoline 2-Imidazoline, 2-((N-(m-hydroxyphenyl)-p-toluidino)methyl)- 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)-pheno 3-(N-2-imidazolin-2-ylmethyl-p-toluidino)phenol 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl-(4-methylphenyl)-amino]phenol 3-[(4,5-dihydro-1h-imidazol-2-yl)methyl-(4-methyl |
| CAS Number | 50-60-2 |
| MDL Number | MFCD00242985 |
| Chemical Name Translation | |
| Wiswesser Line Notation | T5M CN BUTJ B1NR CQ&R D1 |
| Beilstein Registry Number | 0272944 |
| PubChem Substance ID | 5775 |
| InChI | InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) |
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安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - tremor Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold REFERENCE : SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 81,352,1951
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 100 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7(Suppl 1),72,1984
其他信息
- Sigma Aldrich:50-60-2(sigmaaldrich)
- MSDS 信息:3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl-(4-methylphenyl)-amino]phenol(50-60-2).msds
- MOL 文件:50-60-2.mol
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