2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione 2-(10-羟基癸基)-5,6-二甲氧基-3-甲基-1.4-苯醌

CAS 58186-27-9 MFCD00274552

化学结构图

58186-27-9
SMILES: COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O

化学属性

Mol. FormulaC19H30O5
Mol. Weight338
Melting Point51.0 to 55.0 deg-C

别名和识别编码

Chemical Name2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
CAS Number58186-27-9
Synonym Daruma Idebenone Avan CV 2619 Idevenone 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone 2-(10-Hydroxydecyl)-5,6-methoxy-3-methyl-2,5-cyclohexadiene-1,4-dione Mnesis
Chemical Name Translation2-(10-羟基癸基)-5,6-二甲氧基-3-甲基-1.4-苯醌
MDL NumberMFCD00274552
Beilstein Registry Number2001459
LabNetwork Molecule IDLN00194306
Reaxys-RN2001459
PubChem Substance ID160871272
Merck Number4888
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic.

相关文献及参考

  • Barkworth, M.F., et al.: Arzneim.-Forsch., 35, 1704 (1985),
  • Kobayashi, T., et al.: J. Pharmacobio-Dyn., 8, 448 (1985),
  • Zs-Nagy, I., et al.: Arch. Gerontol. Geriatr., 11, 177 (1990),

安全信息

WGK Germany3
RTECSGU5290000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,3931,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,3931,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 830 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (R

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 757 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saie

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环

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