R 59022

CAS 93076-89-2 MFCD00055114

化学结构图

93076-89-2
SMILES: Cc1[n]c2[s]cc[n]2c(=O)c1CCN1CCC(CC1)=C(c1ccccc1)c1ccc(F)cc1

化学属性

Mol. FormulaC27H26FN3OS
Mol. Weight459.58

别名和识别编码

Chemical NameDiacylglycerol Kinase Inhibitor I
Synonym 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin­yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin­yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one R59022 R59022
MDL NumberMFCD00055114
PubChem Substance ID24893986
CAS Number93076-89-2
Chemical Name Translation
InChIKeyMFVJXLPANKSLLD-UHFFFAOYSA-N
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分类

  • {SNA} Bioactive Small Molecule Alphabet
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, D-DIF, Diacylglycerol kinase, Diacylglycerol kinase (DAGK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase Regulators, Kinase/Phosphatase Biology, Lipids in Cell Signaling, Phospholipid Metabolism, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, D-DIF, Diacylglycerol kinase,

相关文献及参考

  • [2]. Nunn DL, et al. A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J. 1987 May 1;243(3):809-13.
  • [3]. Jones JA, et al. Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenalinerelease and phosphoinositide hydrolysis in chromaffin cells. Br J Pharmacol. 1990 Nov;101(3):521-6.
  • [4]. Boroda S, et al. Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists. Biochem Pharmacol. 2017 Jan 1;123:29-39.
  • [5]. Stewart CM, et al. A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells. Viruses. 2019 Mar 1;11(3). pii: E206.
  • Nunn, et al., A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem. J. 243 , 809, (1987) 摘要
  • [1]. de Chaffoy de Courcelles DC, et al. R 59 022, a diacylgly

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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