Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 艾塞那肽
CAS 133514-43-9 MFCD00283195
化学结构图
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
化学属性
| Mol. Weight | 3369.76 |
|---|---|
| Mol. Formula | C149H234N40O47S |
别名和识别编码
| MDL Number | MFCD00283195 |
|---|---|
| CAS Number | 133514-43-9 |
| Chemical Name | Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Synonym | Exendin Fragment 9-39 |
| InChIKey | WSEVKKHALHSUMB-MVNVRWBSSA-N |
| Chemical Name Translation | 艾塞那肽 |
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分类
- {SNA} Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Exendin, GLP-1 Receptor Ligands, Hormones, Obesity Peptides, Obesity Research, Other Obesity Research Products, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究
- {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, E, Exendin, GLP-1 Receptor Ligands, Hormones, Obesity Peptides,
- {SNA} Bio
- Bioactive Small Molecules, Cell Biology,
相关文献及参考
- [2]. De León DD, et al. Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting secretion. J Biol Chem. 2008 Sep 19;283(38):25786-93.
- Baggio, L., et al., Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice. Endocrinology 141 , 3703-3709, (2000) 摘要
- Gunn, I., et al., Central glucagon-like peptide-I in the control of feeding. Biochem. Soc. Trans. 24 , 581-584, (1996) 摘要
- Merck 14 ,3914
- Perfetti, R., et al., Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141 , 4600-4605, (2000) 摘要
- [1]. Calabria AC, et al. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital owing to inactivating mutations in the ATP-sen
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