• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} AMPK通路抑制剂和激活剂, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, P, PER - POLA, 有氧糖酵解（Warburg效应）, 有氧糖酵解（Warburg效应）抑制剂, 癌症代谢, 癌症研究, 细胞生物学
• {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Cancer Metabolism, Cell Biology, Inhibitors and Activators of the AMPK pathway, Inhibitors of Aerobic Glycolysis (the Warburg Effect), P, PER - POLA, 有氧糖酵解（Warburg效应）, 癌症研究
• {SNA} Alphabetical Index of Analytical Standards, Aerobic Glycolysis (the Warburg Effect),
• {SNA} Alphabetical Index of Analytical Standards, Analyt

相关文献及参考

• Merck: 14,7231

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00094

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 81,3728,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 407 mg/kg
TOXIC EFFECTS :
   Endocrine - hypoglycemia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,393,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,181,1994

其他信息

• MSDS 信息:1-Phenethylbiguanide hydrochloride(834-28-6).msds
• MSDS 信息:Phenformin(114-86-3).msds
• Sigma Aldrich:834-28-6(sigmaaldrich)
• 用途一:聚苯并咪唑可制成各种用品如玻璃布层压板、模塑料薄膜、胶粘剂、绝缘漆、泡沫塑料及纤维等。层压板可用于飞机和航天的雷达天线罩、印刷线路板等。还用于绝缘材料、隔离层、耐辐射材料等。
• 上游原料:多聚磷酸 --> N,N-二甲基乙酰胺 --> 双氰胺 --> 预聚物 --> 间苯二甲酰氯 --> 间苯二甲酸二苯酯 --> 盐酸联苯胺 --> 高沸点溶剂
• 方法一:聚苯并咪唑的制备一般有三种方法: 高温溶液缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯胺盐酸盐与间苯二甲酸二苯酯。在高沸点溶剂和多磷酸存在下，于200℃反应数小时，用水沉淀聚合物，洗涤、干燥得预聚物。然后在250-300℃高温脱水环化得聚苯并咪唑。该法易制得高分子量产品。 低温溶液缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯与间苯二甲酰氯在二甲基乙酰胺等强极性溶剂中，以吡啶为酸吸收剂，于低温(0℃以下)进行缩聚制得预聚物，加入沉淀剂，分离、洗涤、干燥预聚物，再于250-300℃高温脱水环化制得聚苯并咪唑。 熔融缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯和间苯二甲酸二苯酯加入反应釜中，在氮气保护下，于260℃反应1-2h，脱苯酚生成聚氨基酰胺预聚物，经粉碎，再于385-400℃高真空脱水环化3-4h，可制得聚苯并咪唑。
• 用途二:本品为降血糖药，以成年型糖尿病的疗效约为88%，适用于各类型的糖尿病。小鼠口服LD50为450mg/kg。
• 方法二:由苯乙胺盐酸盐与双氰 胺在142℃左右加热反应，经后处理、精制而得。
• 用途一:用作降血糖药
• 上游原料:双氰胺
• Sigma Aldrich:114-86-3(sigmaaldrich)
• MOL 文件:834-28-6.mol
• MOL 文件:114-86-3.mol