1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride 1-(4-氯苯基)-6,6-二甲基-1,6-二氢-1,3,5-三嗪-2,4-二胺盐酸盐

CAS 152-53-4 MFCD00035308

化学结构图

152-53-4
SMILES: CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1.Cl

化学属性

Mol. FormulaC11H15Cl2N5
Mol. Weight288

别名和识别编码

Chemical Name1-(4-Chlorophenyl)-6,6-Dimethyl-1,6-Dihydro-1,3,5-Triazine-2,4-Diamine Hydrochloride
CAS Number152-53-4
Synonym 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride BN 2410 Cycloguanil Hydrochloride NSC 3074 Chloroguanide Triazine Hydrochloride 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-,
Chemical Name Translation1-(4-氯苯基)-6,6-二甲基-1,6-二氢-1,3,5-三嗪-2,4-二胺盐酸盐
MDL NumberMFCD00035308
Wiswesser Line NotationT6N CN EN BHJ AR DG& B1 B1 DZ FZ &GH
LabNetwork Molecule IDLN00198324
PubChem Substance ID9048
InChIInChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
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分类

  • aromatics
  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Antimalarial drug

相关文献及参考

  • ##############################################################################################################################
  • [1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

安全信息

RTECSGU2625000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 24 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,487,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATMPA2 Annals of Tropical Medicine and Parasitology.  (Grune & Stratton,
   Inc., POB 6280, Duluth, MN 55806)  V.1-    1907-  Volume(issue)/page/year:
   74,393,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,487,1971

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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