3,12-Bis(3-chloro-2-hydroxypropyl)-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dichloride 3,12-双(3-氯-2-羟基丙基)-3,12-二氮杂-6,9-二恶唑二螺[5.2.5.2]十六烷

CAS 23476-83-7 MFCD00357496

化学结构图

23476-83-7
SMILES: [Cl-].[Cl-].OC(CN1CC[N+]2(CC[N+]3(CC2)CCN(CC(O)CCl)CC3)CC1)CCl

化学属性

Mol. Weight482.38
Mol. FormulaC18H36Cl2N4O2.2Cl

别名和识别编码

Chemical Name二氯化物 Prospidium Chloride
CAS Number23476-83-7
Alfabeta NameBISCHLOROHYDROXYPROPYLDIAZADIAZONIADISPIROHEXADECANEDICHLORIDE 31232312695252...[]()--------,,,
MDL NumberMFCD00357496
Synonym 3,12-Bis(3-chloro-2-hydroxypropyl)-3,6,9,12-tetraazadispiro[5.2.5.2]hexadecan-6,9-ium Chloride Prospidine NSC 166100 Prospidium chloride
Chemical Name Translation3,12-双(3-氯-2-羟基丙基)-3,12-二氮杂-6,9-二恶唑二螺[5.2.5.2]十六烷
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • It is useful as an antitumor agent and does not inhibit hematopoiesis.

相关文献及参考

  • Trybala, E., et al.: J. Biol. Chem., 273, 5047

安全信息

Warnings IRRITANT
RTECSHM1160000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 994 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 47,207,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 16,880,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 gm/plate
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,35,1978

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 26,309,1980

系列性分类

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