TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 9,730,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 57 ug/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NYSJAM New York State Journal of Medicine.  (Medical Soc. of the State of
   New York, POB 5405, Lake Success, NY 11042)  V.1-    1901-
   Volume(issue)/page/year: 61,83,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 71800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc.,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - nausea or vomiting
REFERENCE :
   PRACAK Practitioner.  (Morgan-Grampian Ltd., 40 Beresford St., Woolwich,
   London SE18 6BQ, UK) V.1-    1868-  Volume(issue)/page/year: 197,348,1966