4-Chloro-N-Methylpiperidine N-甲基-4-氯哌啶

CAS 5570-77-4 MFCD00044489

化学结构图

5570-77-4
SMILES: CN1CCC(Cl)CC1

化学属性

Mol. FormulaC6H12ClN
Mol. Weight133.62
Boiling Point202.4°C at 760 mmHg
Refractive index1.4670 to 1.4710
Appearance 具有无色至淡黄色透明的特殊气味的液体
Melting Point160-165 °C
Density1.02
Flash Point76.2°C

别名和识别编码

Chemical Name4-Chloro-N-Methylpiperidine
CAS Number5570-77-4
Alfabeta NameCHLOROMETHYLPIPERIDINE 41---
MDL NumberMFCD00044489
Chemical Name TranslationN-甲基-4-氯哌啶
Synonym 4-Chloro-1-methylpiperidine {LY} 4-Chloro-1-methylpiperidine {} {LY} 4-Chloro-1-methylpiperidine {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-1-methylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlor
PubChem Substance ID79342
Beilstein Registry Number103023
Reaxys-RN103023
EC Number226-942-4
InChIKeyMYGXGCCFTPKWIH-UHFFFAOYSA-N
LabNetwork Molecule IDLN00174605
InChIInChI=1S/C6H12ClN/c1-8-4-2-6(7)3-5-8/h6H,2-5H2,1H3
Canonical SMILESCN1CCC(CC1)Cl
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Piperidines

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P302+P361+P354
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Signal word Danger Warning
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R10 Flammable 易燃
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Hazard Class3
UN Number 1993
Packing GroupIII
Hazard Codes 3 C Xi
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • 方法一:可用1-甲基-4-哌啶酮经催化氢化，生成1-甲基-4-羟基哌啶，然后以氯化亚硫酰氯化制得该品。
  • 用途一:重要的医药中间体，用于抗组胺类药如酮替芬、苯噻啶、氯雷他啶等的合成
  • 用途二:苯噻啶、酮替芬、盐酸赛庚啶的中间体。
  • MOL 文件:5382-19-4.mol
  • 下游产品:1-甲基-4-氯哌啶盐酸盐 --> 1-(1-甲基哌啶-4-基)哌嗪
  • 上游原料:氧氯化硫 --> 4-羟基哌啶 --> N-甲基-4-哌啶酮
  • MOL 文件:5570-77-4.mol

系列性分类

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