Monocrotophos O,O-二甲基-2-甲基氨基甲酰基-1-甲基乙烯基磷酸酯

CAS 6923-22-4 MFCD00055291

化学结构图

6923-22-4
SMILES: CNC(=O)/C=C(\C)OP(=O)(OC)OC

化学属性

Mol. FormulaC7H14NO5P
Mol. Weight223.19
Melting Point54-55°C
Boiling Point125°C
SolubilitySoluble in water, acetone, and alcohol.
Density1.0
Flash Point-18 °C

别名和识别编码

Chemical NamePhosphoric acid, dimethyl ester, ester with(E)-3-hydroxy-N-methylcrotonamide
CAS Number6923-22-4
Synonym dimethyl pho Dimethoxyphosphinyloxy-N-methyl-cis-crotonamide monocos apadrin HUKRON Dimethy DIMETHYL CIS-1-METHYL-2-(METHYLCARBAMOYL) VINYL PHOSPH Parryfos MACABRE Corop Monicil Dimethyl (E)-1-methyl-2-(methylcarbamoyl)vinyl phosphate; Phosphoric acid (E)-dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl ester; Dimethoxyphosphinyloxy-N-methyl-cis-crotonamide; Azodrin; Biloborn; Corophos; Monocil; Nuvacron; Parryfos Croton 36 (E)-Dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate 磷胺粉剂[含量3%~30%] 纽瓦克 Dimethyl-1-methyl-2-(methylcarbamoyl)vinylphosphat SD-9129乳剂 O,O-二甲基-2-甲基氨基甲酰基-1-甲基乙烯基磷酸酯 ######## MONOCRON dimethyl (e)-1-m Phosphoric acid, dimethyl (1E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl ester (E)-二甲基-1-甲基- Apadrin (E)-Dimethyl-1-methyl-3-methylamino-3-oxo-1-propenylphosphorsäureester ENT 27,129 3-Hydr Dimethyl-(E)-1-methyl-2-(methylcarbamoyl)-vinylphosphat phosphoric acid, dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenylester, (E)- LUPHOS(TM) Azodrin insecticide O,O-二甲基-O-(1-甲基-2-甲基甲酰)乙烯基磷酸酯 Phosphate de dimethyle et de 2-methylcarbamoyl 1-methyl vinyle BALWAN E-Monocrotophos Monocil monocil corophos Crotonamide, 3-hydroxy-N-methyl-, dimethylphosphate, (E)- Monocil 40 dimethyl ( Phosphoric acid, dimethyl ester, ester with 3-hydroxy-N-methylcrotonamide, (E)- 3-hydroxy-N-methyl-cis-crotonamide dimethyl phosphate
MDL NumberMFCD00055291
EC Number230-042-7
Beilstein Registry Number2331934
Chemical Name TranslationO,O-二甲基-2-甲基氨基甲酰基-1-甲基乙烯基磷酸酯
Wiswesser Line Notation1OPO&O1&OY1&U1VM1
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分类

  • Agro-Products
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {uni_hamburg} no charge; amide; 1fragment
  • {SA} Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, H-M, Insecticides, M, METI - MZ, Method Specific, Oeko-Tex Standard 100, Organophorous, Pesticides, Pesticides & Metabolites
  • {SNA} Acaricides, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, Insecticides, M,

产品应用

  • 速效广谱杀虫剂,主要用于各种作物上防治螨类、食吸甲虫、棉铃虫等。

相关文献及参考

  • Short: EINECS
  • Short: IV/8A
  • Patel, I. et al.: Ind. J. Agric. Sci., 67, 83 (1997); Rao, V.L. et al.: Ind. J. Agric. Sci., 54, 209 (1984); Kinzer, R.E. et al.: J, Econ. Entomol., 69, 697 (1976);
  • Merck: 14,6251

安全信息

RTECSTC4375000
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
  • H300+H330
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T+;N,N,T+,Xn,F T+,N T+;N
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S1/2 None 上锁保管并避免儿童触及;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
Risk Statements
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R50/53
  • R38 Irritating to skin 刺激皮肤
  • R36 Irritating to eyes 刺激眼睛
  • R11 Highly flammable 非常易燃
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
UN Number 2783 UN 2783
Storage condition 0-6°C
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品
{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB277-077

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 3540 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,49,1967

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 19,47,1978

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 63 mg/m3/4H
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or

{hazard

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 12500 ng/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and T

TYPE OF TES

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 2 pph
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-138973

TYPE OF T

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 188,311,1987

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 12500 ug/kg
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 53,801,1988

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 53,801,1988

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Bird - chicken
DOSE/DURATION           : 5 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 292,231

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16800 ug/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   INJPD2 Indian Journal of Pharmacology.  (Dept. of Pharmacology, Baranas
   Hindu Univ., Varanasi 221 005, India)  V.1-    1968(?)-
   Volume(issue)/page/year: 26,126,1994

其他信息

  • MOL 文件:6923-22-4.mol
  • RTECS号:TC4375000
  • 毒害物质数据:6923-22-4(Hazardous Substances Data)
  • HazardClass:6.1(a)
  • NIST化学物质信息:Monocrotophos(6923-22-4)
  • PackingGroup:II
  • 有机磷杀虫剂:久效磷 是一种高效内吸性有机磷杀虫剂,有顺、反两种异构体,工业品是这两种异构体的混合物,常温下为褐色半固体,中性及酸性条件下较稳定;碱性条件下易分解,不可与碱性物质混用;对日光较稳定;对铁和黄铜有腐蚀性;能与水混溶,可溶于乙醇、丙酮,稍溶于二甲苯和煤油,难溶于脂肪烃,具有很强的触杀和胃毒作用。杀虫谱广,速效性好,残留期长,对刺吸、咀嚼和蛀食性的多种害虫有效。能防治稻螟、稻纵卷叶虫、稻苞虫、稻螟蛉、稻叶蝉、稻飞虱、抗性蚜虫、红蜘蛛、棉铃虫、棉红铃虫等多种害虫。作用机制为抑制昆虫体内的乙酰胆碱酯酶。久效磷还有一定的杀卵作用,适用于防治棉花、水稻、大豆、森林等作物上的多种害虫。 毒性 久效磷对鸟类及其他野生动物高毒;对鱼毒性较低;对虾类毒性高;对蜜蜂毒性高;对人畜有剧毒,但经皮毒性(与皮肤接触的毒性)低,使用时仍须注意安全。一般使用下对作物安全,但在寒冷地区对某些品种的苹果、樱桃、扁桃、桃和高粱有轻微药害。
  • EPA化学物质信息:Phosphoric acid, dimethyl (1E)-1-methyl-3-(methylamino)- 3-oxo-1-propenyl ester(6923-22-4)
  • 有轻微的酯味,能与水混溶,可溶于丙酮、乙醇、二氯甲烷,稍溶于二甲苯、乙醚,不溶于石油醚、柴油和煤油。在碱性介质中易分解,故不能与碱性农药混用。
  • 图谱信息:久效磷(6923-22-4)核磁图( 13 CNMR) 久效磷(6923-22-4)质谱(MS) 久效磷(6923-22-4)核磁图( 1 HNMR) 久效磷(6923-22-4)红外图谱(IR1)

系列性分类


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