Sodium (4Ar,6R,7R,7As)-6-(6-Amino-8-((4-Chlorophenyl)Thio)-9H-Purin-9-Yl)-7-Hydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-2-Olate 2-Oxide (4aR,6R,7R,7aS)-6-(6-氨基--8-((4-氯苯基)硫基)-9H-嘌呤-9-基)-7-羟基四氢-4H-呋喃并[3,2-d][1,3,2]二氧磷杂环己烷-2-醇-2-氧化物钠盐

CAS 93882-12-3 MFCD00057683

化学结构图

93882-12-3
SMILES: [Na+].NC1=NC=NC2=C1N=C(SC1C=CC(Cl)=CC=1)N2[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O

化学属性

Mol. FormulaC16H14ClN5NaO6PS
Mol. Weight493.79

别名和识别编码

Chemical NameSodium (4Ar,6R,7R,7As)-6-(6-Amino-8-((4-Chlorophenyl)Thio)-9H-Purin-9-Yl)-7-Hydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-2-Olate 2-Oxide
Synonym pCPT-cAMP
MDL NumberMFCD00057683
PubChem Substance ID24278024
CAS Number93882-12-3
EC Number299-413-9
Chemical Name Translation(4aR,6R,7R,7aS)-6-(6-氨基--8-((4-氯苯基)硫基)-9H-嘌呤-9-基)-7-羟基四氢-4H-呋喃并[3,2-d][1,3,2]二氧磷杂环己烷-2-醇-2-氧化物钠盐
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分类

  • Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology
  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Sm

相关文献及参考

  • Desaphy, J.F., et al., Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers. Am. J. Physiol. 275 , C1465-C1472, (1998) 摘要
  • Chavis, P., et al., Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells. Neuron 20 , 773-781, (1998) 摘要
  • Connolly, B.J., et al., 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem. Pharmacol. 44 , 2303-2306, (1992) 摘要
  • Ali, H., et al., Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cβ3 phosphorylation by protein kinase A. J. Biol. Chem. 273 , 11012-11016, (1998) 摘要
  • Jun, C.D., et al., Cyclic adenosine monophosphate inhibits nitric oxide-induced apoptosis in human leukemic HL-60 cells. Cell. Immunol. 183 , 13-21, (1998) 摘要
  • Funderud, A., et al., Isoform-specific Regulation Of Immune Cell Reactivity By The Catalytic Subunit Of Protein Kinase A (PKA). Cell Physiol. Biochem. 21 , 274-81, (2009)
  • Liu, X., et al., Induction Of Cell Cycle Arrest At G1 And S Phases And CAMP-dependent Differentiation In C6 Glioma By Low Concentration Of Cycloheximide. BMC Cancer 10 , 684, (2010) 摘要
  • Zhang, J., et al., Inhibition Of Glyceroneogenesis By Histone Deacetylase 3 Contributes To Lipodystrophy In Mice With Adipose Tissue Inflammation. Endocrinology 152 , 1829-38, (2011) 摘要
  • Fontainhas, A.M., and Townes-Anderson, E., RhoA Inactivation Prevents Photoreceptor Axon Retraction In An In Vitro Model Of Acute Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 52 , 579-87, (2011) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism

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