2-(2-Chlorophenyl)-5,7-Dihydroxy-8-((3S,4R)-3-Hydroxy-1-Methylpiperidin-4-Yl)-4H-Chromen-4-One Hydrochloride 2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]-4H-苯并吡喃-4-酮盐酸盐

CAS 131740-09-5 MFCD05860967

化学结构图

131740-09-5
SMILES: Cl.CN1C[C@@H](O)[C@H](CC1)C1C2OC(=CC(=O)C=2C(O)=CC=1O)C1C=CC=CC=1Cl |&1:4,6|

化学属性

Mol. FormulaC21H21Cl2NO5
Mol. Weight438.3

别名和识别编码

Chemical Name2-(2-Chlorophenyl)-5,7-Dihydroxy-8-((3S,4R)-3-Hydroxy-1-Methylpiperidin-4-Yl)-4H-Chromen-4-One Hydrochloride
CAS Number131740-09-5
Synonym rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride Alvocidib Hydrochloride HL 275 MDL 107826A NSC 649890
Chemical Name Translation2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]-4H-苯并吡喃-4-酮盐酸盐
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分类

  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.

相关文献及参考

  • Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998),
  • Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002),
  • Raju, U., et al.: Cancer Res., 63, 3263 (2003),

系列性分类

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