Clomifene 化合物
CAS 911-45-5 MFCD00599444
化学结构图
SMILES: CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1
化学属性
| Mol. Weight | 406.00 |
|---|---|
| Mol. Formula | C26H28ClNO |
别名和识别编码
| InChIKey | GKIRPKYJQBWNGO-QPLCGJKRSA-N |
|---|---|
| Chemical Name | T21375 Clomiphene Hydrochloride (E/Z Mixture) |
| Wiswesser Line Notation | GYR&UYR&R DO2N2&2 |
| Synonym | 1-(p-(beta-Diethylaminoethoxy)-phenyl)-1,2-diphenylchloroethylene 2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine 2-(p-(beta-Chloro-alpha-phenylstyryl)phenoxy)-triethylamine Chloramiphene Citrate, Clomiphene Clomid Clomide Clomifen Clomifene Clomiphene Clomiphene B Clomiphene Citrate Clomiphene Hydrochloride Clostilbegit Dyneric Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl- Gravosan Hydrochloride, Clomiphene Klostilbegit Serophene |
| CAS Number | 911-45-5 |
| Chemical Name Translation | 化合物 |
| PubChem Substance ID | 2800 |
| InChI | InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3 |
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安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 15 mg/kg/13W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Spinal Cord - tumors Skin and Appendages - tumors REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,1176,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 552 mg/kg/69W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Blood - leukemia REFERENCE : PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 11,440,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 20,419,1961
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 5 mg/kg/5D-I TOXIC EFFECTS : Skin and Appendages - dermatitis, irritative (after systemic exposure) REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,380,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 20,419,1961
TYPE OF TEST : Morphological transformation ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 2100 mg/kg/6W (Continuous) REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 46,195,1989
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 500 ug/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 18,303,1997
TYPE OF TEST : Micronucleus test TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 200 ug/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 18,303,1997
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 4500 ug/kg SEX/DURATION : female 8-22 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 16,195,1965
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE : 10 mg/kg SEX/DURATION : female 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : UMJOAJ Ulster Medical Journal. (Ulster Medical Soc., POB 222, Belfast BT9 7AD, UK) V.1- 1932- Volume(issue)/page/year: 45,59,1976
TYPE OF TES
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Hum
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE : 5 mg/kg SEX/DURATION : female 5 day(s) pre-mating TOXIC EFFECT
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 6 mg/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/pag
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