5-Amino-2,4(1H,3H)-pyrimidinedione 5-氨基-2,4(1H,3H)-嘧啶二酮

CAS 932-52-5 MFCD00006025

化学结构图

932-52-5
SMILES: NC1=CNC(=O)NC1=O

化学属性

Mol. FormulaC4H5N3O2
Mol. Weight127
Density1.422
Melting Point>300
TSCAYes
Solubility0.5 G/L (20 ºC)

别名和识别编码

Chemical Name5-Amino-2,4(1H,3H)-pyrimidinedione
Synonym -Amino-2,4-pyrimidinediol 2,4-Dihydroxy-5-aminopyrimidine 3h)-pyrimidinedione,5-amino-4(1h 5-AMINO-2,4-DIHYDROXYPYRIMIDINE 5-AMINO-2,4-DIHYDROXYPYRIMIDINE[5-2,6] 5-AMINO-2,4-PYRIMIDINEDIOL 5-Amino-1H-pyrimidine-2,4-dione 5-Amino-2,4(1H,3H)-pyrimidinedione 5-Amino-2,4-dihydroxypyrimidine 5-Amino-2,4-dihydroxypyrimidine, 5-Amino-2,4-pyrimidinediol 5-Amino-2,4-dihydroxypyrimidine,5-Amino-2,4-pyrimidinediol 5-Amino-2,4-pyrimidinediol 5-Amino-2,4-pyrimidinediol; 5-Amino-2,4-dihydroxypyrimidine 5-Aminopyrimidine-2,4(1H,3H)-dione 5-Aminouracil 5-Aminouracil ,98% 5-Aminouracil,97% 5-amino-1H-py 5-amino-uraci 5-氨基-2,4-二羟基嘧啶 5-氨基-2,4-二羟基嘧啶 5-氨基-2,4-嘧啶二醇 5-氨基-2,6-二羟基嘧啶 5-氨基尿
MDL NumberMFCD00006025
CAS Number932-52-5
EC Number213-252-3
Beilstein Registry Number127250
PubChem Substance ID87562407
Reaxys-RN127250
Chemical Name Translation5-氨基-2,4(1H,3H)-嘧啶二酮
Wiswesser Line NotationT6MVMVJ EZ
LabNetwork Molecule IDLN00243291
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分类

  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
  • {uni_hamburg} no charge; nitrogen heterocycle; 6RingOnly; 6ring; urea; amide; lactame; 1fragment

产品应用

  • 用作生化研究试剂

相关文献及参考

  • Condensation with crotonaldehyde gives 2,4-dioxo-6-methylpyrido[3,2-d]pyrimidine: J. Chem. Soc. (C), 1745 (1967). An improved procedure has been used in synthesis of inhibitors of human thymidylate synthase: J. Med. Chem., 27, 1710 (1984), and of dihydrofolate reductases: J. Med. Chem., 39, 1836 (1996):
  • Short: III/20a
  • Short: EINECS
  • Review of the use of uracils as starting materials in heterocyclic synthesis: Adv. Heterocycl. Chem., 55, 130 (1992).

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSYQ8740000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 37,334,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 300 mg/L
REFERENCE :
   JGMIAN Journal of General Microbiology.  (Soc. for General Microbiology,
   Journal Sales, 62 London Rd., Reading, RG1 5AS, UK)  V.1-    1947-
   Volume(issue)/page/year: 18,543,1958

其他信息

  • TCI Shanghai:5-氨基尿嘧啶 5-Aminouracil,>;98.0%(LC)(932-52-5)
  • 上游原料:盐酸 --> 氨 --> 连二亚硫酸钠 --> 5-硝基尿嘧啶
  • Alfa Aesar:5-氨基脲嘧啶,97% 5-Aminouracil, 97%(932-52-5)
  • F:10-23
  • 储运特性:库房通风低温干燥
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 毒性分级:中毒
  • MSDS 信息:5-Aminouracil(932-52-5).msds
  • 可燃性危险特性:可燃;高温产生有毒氮氧化物烟雾
  • Sigma Aldrich:932-52-5(sigmaaldrich)
  • 5-氨基尿嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0898 5-氨基尿嘧啶 5-Aminouracil 5G 539元 2014/06/02 A0898 5-氨基尿嘧啶 5-Aminouracil 25G 1500元 2010/06/21 226820025 5-氨基尿嘧啶 5-Aminouracil 98% 2.5 GR 253元
  • 图谱信息:5-氨基尿嘧啶(932-52-5)红外图谱(IR2) 5-氨基尿嘧啶(932-52-5)质谱(MS) 5-氨基尿嘧啶(932-52-5)红外图谱(IR1)
  • 用途一:用作生化研究试剂
  • 检测方法:HPLC
  • 急性毒性:参考值: 非肠道-小鼠LDL0: 2400 毫克/公斤
  • Acros Organics:5-氨基尿嘧啶 5-Aminouracil, 98%(932-52-5)
  • MOL 文件:932-52-5.mol
  • 溶于稀酸，不溶于水。具两性。可形成金属盐和苦味酸盐
  • 外观性质:针状结晶，溶于稀酸，不溶于水。具两性。可形成金属盐和苦味酸盐熔点：>300 °C
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C4 to C5 - Pyrimidines
  1. C9 to C46

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