Sulfamethazine 磺胺二甲基嘧啶

CAS 57-68-1 MFCD00006066

化学结构图

57-68-1
SMILES: Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

化学属性

Mol. FormulaC12H14N4O2S
Mol. Weight278
Density1.392
Melting Point198-201
TSCAYes
Solubility150MG/100ML (29 ºC)
Stability对光敏感
Appearance 白色或微黄结晶或粉末。熔点176℃。几乎不溶于水（溶解度：29℃，150mg/100ml；37℃，192mg/100ml），该品在热乙醇中溶解，不溶于乙醚，易溶于稀酸或稀碱溶液。无嗅，味微苦，遇光颜色逐渐变深。

别名和识别编码

Chemical NameSulfamethazine
CAS Number57-68-1
Synonym 2-(p-aminobenzenesulfonamido)-4,6-dimethylpyrimidine 4,6-Dimethyl-2-sulfanilamidopyrimidine 4,6-Dimethylsulfadiazine,Sulfadimidine 4,6-二甲基磺胺嘧啶 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺 磺胺二甲嘧啶 4-AMINO-N-(4,6-DIMETHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE 4-Amino-N-(4,6-Dimethyl-2-pyrimidinyl)benzenesulfonam 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺 A-502 Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)- Cremomethazine Diazil Diazyl N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide Pirmazin S SULFADIMIDIN Sulfadimerazine Sulfadimesine Sulfadimezine Sulfadimidine Sulfamethazine Sulfamethiazine Sulphamezathine Sulphamidine Sulphodimezine sulfadimidine sulfamethazine {PubCh
EC Number200-346-4
Beilstein Registry Number261304
MDL NumberMFCD00006066
PubChem Substance ID5327
Reaxys-RN261304
Merck Number8905
Chemical Name Translation磺胺二甲基嘧啶
Wiswesser Line NotationT6N CNJ BMSWR DZ& D1 F1
LabNetwork Molecule IDLN00220271
InChIInChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Antibiotics A to Z, Antibiotics N-S, 抗生素, 生化试剂
  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecules, Biochemicals and Reagents,

产品应用

  • Antibacterial.

相关文献及参考

  • Merck:8905 Beilstein:25(5)10,250
  • Short: IV/8A
  • Short: III/39
  • Short: EINECS
  • Papostephanou, M., et al.: Anal. Profiles Drug Subs., 7, 401 (1978),
  • Merck:8905

安全信息

Signal word Warning
GHS Symbol
WGK Germany2
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P302+P352
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P308+P313
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P342+P311
  • P342+P316
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSWO9275000
Personal Protective Equipment Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 0-10 避光保存。 0-10°C 2-8°C
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 104 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   28,157,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 419 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,455,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   ACRAAX Acta Radiologica.  (Stockholm, Sweden)  V.1-58, 1921-62.  For
   publisher information, see ACRDA8.  Volume(issue)/page/year: 37,258,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,392,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1060 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   16,804,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   27,141,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIPHAH Dissertationes Pharmaceuticae.  (Warsaw, Poland)  V.1-17, 1949-65.
   For publisher information, see PJPPAA.  Volume(issue)/page/year: 11,149,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent

TY

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 46200 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6850 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-151035

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 25200 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB85-105690

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPO

其他信息

  • 上游原料:碳酸钠 --> 乙酰丙酮 --> 环己酮 --> 磺胺脒
  • Sigma Aldrich:57-68-1(sigmaaldrich)
  • 磺胺二甲嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 S0586 磺胺二甲嘧啶 Sulfamethazine 250G 350元 2014/06/02 S0586 磺胺二甲嘧啶 Sulfamethazine 25G 110元 2010/06/21 199300250 磺胺二甲嘧啶 Sulfamethazine 99% 25 GR 341元
  • 方法一:由磺胺脒经与乙酰丙酮环合而得。
  • 几乎不溶于水（溶解度：29℃，150mg/100ml；37℃，192mg/ml），在热乙醇中溶解，不溶于乙醚，易溶于稀酸或稀碱溶液。无嗅，味微苦，遇光颜色逐渐变深。
  • 图谱信息:磺胺二甲嘧啶(57-68-1)红外图谱(IR1) 磺胺二甲嘧啶(57-68-1)核磁图( 1 HNMR) 磺胺二甲嘧啶(57-68-1)核磁图( 13 CNMR) 磺胺二甲嘧啶(57-68-1)质谱(MS) 磺胺二甲嘧啶(57-68-1)红外图谱(IR2)
  • MOL 文件:57-68-1.mol
  • 用途二:用于防治葡萄球菌及溶解性链球菌等的感染，对溶血性链球菌及胸膜炎球菌等细菌有抑制作用，主要治疗禽霍乱、禽伤寒、鸡球虫病等。
  • F:10
  • 用途一:对溶血性链球菌、肺炎球菌及脑膜炎等细菌有抑制作用
  • MSDS 信息:2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine(57-68-1).msds
  • Acros Organics:磺胺二甲基嘧啶 Sulfamethazine, 99%(57-68-1)
  • Alfa Aesar:磺胺二甲基嘧啶,99% Sulfamethazine, 99%(57-68-1)

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Sulfonamides - Chemical Structure Class
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Mechanism of Action - Antibiotics
  4. Interferes with DNA Synthesis - Mechanism of Action
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Mechanism of Action
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Chemical Structure Class
  5. Quinolones and Fluoroquinolones
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Mechanism of Action
  5. Interferes with Cell Wall Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Multi-Drug Resistance and Drug Metabolism
  5. Drug and Xenobiotic Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Antibiotics
  4. Spectrum of Activity
  5. Antibacterial
  6. A - K

相关产品推荐