CAS 290-37-9 MFCD00006122-Pyrazine 吡嗪 -LabNovo

Pyrazine 吡嗪

CAS 290-37-9 MFCD00006122

化学结构图

SMILES: c1cnccn1

化学属性

Mol. Formula	C4H4N2
Mol. Weight	80.09
Boiling Point	118.6°C at 760 mmHg
Melting Point	50-56°C
TSCA	T
Density	1.031
Refractive index	1.5235
Flash Point	55.6°C
Solubility	Soluble in water, alcohol, and ether
Appearance	吡嗪(290-37-9)两个氮原子占1,2两位的称为哒嗪；占1,3两位的称为嘧啶,它们都是吡嗪的同分异构体。吡嗪是无色晶体，熔点54℃，沸点115～116℃（768毫米汞柱），液态的相对密度1.0311（61／4℃）。具有与吡啶类似的气味。溶于水、乙醇、乙醚等。吡嗪是一个很弱的碱。它的芳香性与吡啶类似，很不容易发生亲电取代反应，而对亲核试剂比较活泼。碳原子上的氢被甲基或卤素取代后，卤素或甲基上的氢具有活性。吡嗪及其衍生物可用多种方法合成。
Stability	易吸潮

别名和识别编码

Chemical Name	Pyrazine
CAS Number	290-37-9
Alfabeta Name	PYRAZINE
MDL Number	MFCD00006122
EC Number	206-027-6
Beilstein Registry Number	23,91
Reaxys-RN	103905
Merck Number	7957
PubChem Substance ID	87574722
Synonym	Pyrazine {LY} Pyrazine {} {LY} Pyrazine {} {} {LY} Pyrazine {} {} {} {LY} Pyrazine {} {} {} {} {LY} Pyrazine {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation	吡嗪
Wiswesser Line Notation	T6N DNJ
LabNetwork Molecule ID	LN00110787
InChI	InChI=1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H
Canonical SMILES	C1=NC=CN=C1

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安全信息

Warnings FLAMMABLE

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37 Wear suitable gloves 戴适当手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R11 Highly flammable 非常易燃
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P211 Do not spray on an open flame or other ignition source.? 不要喷洒在明火或其他点火源。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352+P332+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P332+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P370+P378

RTECSUQ2015000

UN Number 1325 UN1325

Hazard statements

H228 Flammable solid 易燃固体
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes 4.1 F;Xi

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves

Packing GroupII

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class4.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2730 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPHAW Progress in Biochemical Pharmacology.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1965-  Volume(issue)/page/year:
   1,542,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2500 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 60 gm/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

其他信息

毒性:可用于食品(FAO/WHO，2001)。
1，4位含两个杂氮原子的杂环化合物。与嘧啶和哒嗪互为同分异构体。溶于水、醇和醚。具有较弱的芳香性，与吡啶类似。不易发生亲电取代反应，但易和亲核试剂发生取代反应。
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg）吡嗪食品食品用香料用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
Alfa Aesar:<1.0%(290-37-9)" href="http://www.alfa.com/zh/GP100w.pgm?DSSTK=A13982&CAS;=290-37-9">吡嗪,99+% Pyrazine, 99+% (dry wt.) water <1.0%(290-37-9)
FEMA:4015
TSCA:T
用途一:用作医药中间体，香精、香料中间体
1，4位两个杂氮原子的杂环化合物。与嘧啶和哒嗪互为同分异构体。溶于水、醇和醚。具有较弱的芳香性，与吡啶类似。不易发生亲电取代反应，但易和亲核试剂发生取代反应。
Sigma Aldrich:290-37-9(sigmaaldrich)
MOL 文件:290-37-9.mol
吡嗪价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 xw050008 吡嗪;1,4-二嗪 100g 600元 2011/04/16 P0544 吡嗪 Pyrazine 500G 3600元 2011/04/16 P0544 吡嗪 Pyrazine 25G 458元
海关编码:29339990
Acros Organics:吡嗪 Pyrazine, 99+%(290-37-9)
图谱信息:吡嗪(290-37-9)红外图谱(IR1) 吡嗪(290-37-9)红外图谱(IR2) 吡嗪(290-37-9)核磁图( 1 HNMR) 吡嗪(290-37-9)核磁图( 13 CNMR) 吡嗪(290-37-9)质谱(MS)
参考质量标准:FAO/WHO，2001 含量(GT-10-4) ≥98% 熔点 53℃
MSDS 信息:1,4-Diazine(290-37-9).msds
TCI Shanghai:1,4-二嗪 Pyrazine,>;98.0%(GC)(290-37-9)
检测方法:GC,NMR
下游产品:氟哌酸 --> 佐匹克隆 --> (6R,7R)-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-[(R)-2-(4-乙基-2,3-二氧代-1-哌嗪甲酰氨基)-2-对羟基苯基-乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 吡喹酮 --> 2-乙酰基吡嗪