2-Methylpyridine 2-甲基吡啶

CAS 109-06-8 MFCD00006332

化学结构图

109-06-8
SMILES: CC1CCCCN1

化学属性

Mol. FormulaC6H7N
Mol. Weight93.13
Density0.943
Refractive index1.4970 to 1.5030
Autoignition Point995 °F
Vapor Density3.2 (vs air)
Boiling Point128°C
Vapor Pressure10 mmHg ( 24.4 °C)
Melting Point-70
Flash Point25°C(lit.)
TSCAYes
Solubility与水混溶,溶于多数有机溶剂。
Stability对光敏感

别名和识别编码

Chemical Name2-Methylpyridine
CAS Number109-06-8
EC Number203-643-7
Beilstein Registry Number20,234
MDL NumberMFCD00006332
Synonym 2-甲基呲啶 2-甲基吡啶 α-picoline o-Methylpyridine .alpha.-Methylpyridine 2-Methylpyridine-d7(2-Picoline),98 atom % D Pyridine, 2-methyl- pyridine,2-methyl- o-Methylpyridine aPicolin α-甲代氮苯 2-Methylpyidine 2-methyl-pyridine Rcra waste number U191 a-Methylpyridine 2-皮考林 pyridine, 2-methyl- α-Picoline 2-甲基吡啶 PICOLINE, alpha ALPHAP alpha-Methylpyridine 2-picoline ALPHA-PICOLINE Picoline α-Methylpyridine o-picoline(2-methylpyridine) rcrawastenumberu191 ai3-2409 α-甲基吡啶,2-皮考啉,α-甲代氮苯 α-甲基吡啶 {
PubChem Substance ID7975
Merck Number7400
Chemical Name Translation2-甲基吡啶
Reaxys-RN104581
Wiswesser Line NotationT6NJ B1
LabNetwork Molecule IDLN00220344
InChIInChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3
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分类

  • {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体

产品应用

  • 检定钴、氰酸盐和铁。有机合成。

相关文献及参考

  • Short: II/27B
  • Short: II/6
  • Short: II/5
  • Merck:14,7400 Beilstein:20,234
  • Merck:14,7400

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R10 Flammable 易燃
  • R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Precautionary statements
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P403+P233
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P241+P242+P243
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P305+P351+P338+P310
  • P304+P340+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P308+P311
  • P303+P361+P353+P310+P363
  • P405 Store locked up. 上锁保管。
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302+H332
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTJ4900000
Packing GroupIII
UN Number UN2313 2313
Hazard Codes T
Hazard Class3
Storage condition Flammables area 密封阴凉避光保存。
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 674 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(12),62,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 790 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(12),62,1980

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(is

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   V

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 7400 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

Restrict 危险品

其他信息

  • 用途一:用作合成医药、染料、树脂的原料,可制取化肥增效剂、除草剂、牲畜驱虫剂、橡胶促进剂、染料中间体等
  • 毒性分级:中毒
  • 有极不愉快的气味。能与乙醇、乙醚混溶,易溶
  • {Chemical
  • 蒸气压:10 mm Hg ( 24.4
  • {Chemica
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 爆炸物危险特性:与空气混合可爆
  • 上游原料:硫酸 --> 氨 --> 苯 --> 丙烯腈 --> 硫酸铵 --> 丙烯醛 --> 4-甲
  • TCI Shanghai:2-甲基吡啶 2-Picoline,>;98.0%(GC)(T)(109-06-8)
  • MSDS 信息:2-甲基吡啶(109-0
  • MOL 文件:109-06-8.mol
  • 2-甲基吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80103628 2-甲基吡啶;α-甲基吡啶; 2-皮考啉;α-噼口哥啉; α-煤膏啶 500ml 94元 2011/08/23 xp4003
  • 方法一:其制备方法是以乙醛为原料,与氨气在催化剂存在下气相反应,反应
  • 类别:易燃液体
  • 上游原料:硫酸 --> 氨 --> 苯 -->
  • 敏感性:Hygroscopic
  • Acros Org
  • 图谱信息:2-甲基吡啶(109-06-8)红外图谱(IR3) 2-甲基吡啶(109-06-8)核磁图( 1 HNMR) 2-甲基吡啶(109-06-8)红外图谱(IR2) 2-甲基吡啶(109-06-8)核磁图( 13 CNMR) 2-甲基吡啶(109-06-8)质谱(MS) 2
  • Alfa Aesar:2-甲基吡啶,98+% 2-Picoline, 98+%(109-06-8)
  • 用途五:检定钴、氰酸盐和铁。有机合成。
  • 方法二:吡啶和甲基吡啶以前都从煤焦化副产中回收,它分布在焦炉煤气、粗苯和焦油中。一般从煤气转移到硫铵母液里的吡啶类水合物沸点都很低,在95-97℃之间,回收得到的粗轻吡啶盐基中,2-甲基吡啶含15%左右,进一步精馏可切取得到2-甲基吡啶。随着吡啶和甲基吡啶用途的扩大,合成法生产吡啶和甲基吡啶不断发展。目前,国外约95%的吡啶及吡啶类化合物是用合成法生产的。主要的合成法有乙醛法、乙炔法、丙烯腈法等。乙醛法 乙醛、甲醛和氨反应,主要产品是2-甲基吡啶、3-甲基吡啶和4-甲基吡啶。乙炔法 乙炔和氨反应,主要产品是2-甲基吡啶和4-甲基吡啶。乙烯法 乙烯和氨反应,主要产品是2-甲基吡啶和2-甲基-5-乙基吡啶。丙烯腈法 丙烯腈和过量丙酮反应,主要产品是2-甲基吡啶。另外,丙烯醛和氨反应主要生成3-甲基吡啶。
  • 下游产品:3-氨基-6-甲基吡啶 --> 2-氨基6-甲基吡啶 --> 2-甲基-4-羧基吡啶 --> 吡啶-2-甲醛 --> 4-甲氧基吡啶-2-甲酸 --> 5-羟基-2-吡啶羧酸 --> 4-羟基吡啶-2-羧酸 --> 4-溴吡啶-2-羧酸 --> 4-硝基-2-甲酸吡啶 --> 4-氯-2-吡啶甲酸 --> 2,2'-联吡啶 --> (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺 --> N-甲基-N-2-(2-吡啶基)胺 --> 氯霉素棕榈酸酯 --> 马来酸氯苯那敏 --> 2-丙醇吡啶 --> 2-(2-吡啶)-苯并咪唑 --> 2-氯甲基吡啶盐酸盐 --> 吡啶醇 --> 2-(溴甲基)吡啶氢溴酸盐 --> 2-吡啶乙肪醛甲碘化物 --> 2-吡啶醛肟甲氯 --> 4-(2-吡啶甲基)苯胺 --> 异丁司特 --> {[(6-甲基-2-吡啶基)氨基]亚甲基}丙二酸二乙酯 --> 比沙可啶 --> 碘化1,2-二甲基吡啶鎓
  • 刺激数据:皮肤- 兔子 10 毫克/ 24小时 轻度; 眼睛- 兔子 0
  • Acros Organics:2-甲基吡啶 2-Picoline, 98%(109-06-8)

系列性分类