3-Hydroxy-1-Methylpiperidine 3-羟基-N-甲基哌啶

CAS 3554-74-3 MFCD00006495

化学结构图

3554-74-3
SMILES: CN1CCCC(O)C1

化学属性

Mol. FormulaC6H13NO
Mol. Weight115.17
Density0.999 g/mL at 25 °C(lit.)
Refractive indexn20/D 1.474(lit.)
Flash Point70 ºC
TSCAYes
Boiling Point76-78 °C/11 mmHg(lit.)

别名和识别编码

Chemical Name3-Hydroxy-1-Methylpiperidine
CAS Number3554-74-3
Alfabeta NameHYDROXYMETHYLPIPERIDINE 31---
MDL NumberMFCD00006495
Synonym 1-甲基-3-羟基哌啶 1-METHYL-3-PIPERIDINOL N-甲基-3-羟基哌啶 1-Methyl-3-hydroxypiperidine N-METHYL-3-HYDROXY PIPERIDINE 1-Methyl-3-piperidinol, 3-Hydroxy-1-methylpiperidine N-Methyl-3-hydroxypiperidine; 1-Methyl-3-piperidinol 六氫啶 3-羟基-N-甲基哌啶 N-METHYL-3-PIPERIDINOL 1-甲基-3-哌啶醇 3-Hydroxy-1-methylpiperidine 97% 1-METHYLPIPERIDIN-3-OL 1-methyl-3-piperidino 3-羟基-1-甲基哌啶 3-Hydroxy-l-methylpiperidine 3-HYDROXY-N-METHYLPIPERIDINE 1-Methyl-3-piperidinol 3-HYDROXY-1-METHYLPIPERIDINE 97+% 1-甲基-3-哌啶醇 3-羟基-1-甲基哌啶 3-HYDROXY-1-METHYLPIPERIDINE N-甲基-3-哌啶醇 NM3PPOL
EC Number222-609-2
Beilstein Registry Number103017
PubChem Substance ID24895628
Chemical Name Translation3-羟基-N-甲基哌啶
InChIKeyUKANCZCEGQDKGF-UHFFFAOYSA-N
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines

相关文献及参考

  • The Na derivative can be used in combination with Ni(OAc) 2 /NaH for desufurization of thioethers, showing dramatic rate enhancement compared with other systems: Tetrahedron Lett ., 39, 8987 (1998).

安全信息

Warnings IRRITANT
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R6/37/38
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard Codes Xi
Restrict 监控化学品

其他信息

  • 上游原料:氢溴酸 --> 镍 --> 氢氧化钾溶液 --> 无水硫酸钾
  • 图谱信息:3-羟基-N-甲基哌啶(3554-74-3)核磁图( 13 CNMR) 3-羟基-N-甲基哌啶(3554-74-3)质谱(MS) 3-羟基-N-甲基哌啶(3554-74-3)红外图谱(IR1) 3-羟基-N-甲基哌啶(3554-74-3)核磁图( 1 HNMR)
  • Alfa Aesar:3-羟基-1-甲基哌啶,99% 3-Hydroxy-1-methylpiperidine, 99%(3554-74-3)
  • 用途一:有机合成中间体。
  • Hazard Note:Irritant
  • Sigma Aldrich:3554-74-3(sigmaaldrich)
  • MOL 文件:3554-74-3.mol
  • 3-羟基-N-甲基哌啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L10829 3-羟基-1-甲基哌啶, 99% 3-Hydroxy-1-methylpiperidine, 99% 5g 174元 2010/05/25 L10829 3-羟基-1-甲基哌啶, 99% 3-Hydroxy-1-methylpiperidine, 99% 25g 561元
  • 方法一:以糠醛为原料，经与甲胺缩合，加氢还原、扩环而得。将糠醛、甲胺、无水乙醇、雷尼镍混合，于85-95℃通入氢气约吸收6h。过滤，用稀硫酸中和至pH为6-7。回收乙醇后用苯提取，提取液加入无水硫酸钾干燥，回收苯后常压分馏，收集150-166℃馏分即得缩合物，收率91%。将上述缩合物与冰醛酸混合，于100-105℃通入干燥的溴化氢气体，通气反应2h。然后放冷至80℃左右，用饱和氢氧化钾溶液中和至pH为8以上。经常压蒸馏、甲苯提取，将提取液进行减压蒸馏，收集74-80℃（2.13kPa）馏分，即得3-羟基-N-甲基哌啶。

系列性分类

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