Nicotine, (+-)-

CAS 22083-74-5 MFCD00065370

化学结构图

22083-74-5
SMILES: CN1CCC[C@@H]1C1C=NC=CC=1 |&1:5|

化学属性

Mol. FormulaC10H14N2
Mol. Weight162.23
Density1.02 g/mL at 25 °C(lit.)
Flash Point101 °C
Appearance D )1.5282，闪点101℃。易溶于乙醇、乙醚、氯仿和石油醚。剧毒，LD 20 )1.0097，比旋光度[α] 本品为消旋体。无色或淡黄色油状液体，有吡啶臭味，味焦辣，易挥发和吸潮，遇光或空气色变深。Bp247℃(分解)，相对密度(d -169°，折射率(n (大鼠，经口)50mg/kg。应避免吸入蒸气、接触皮肤和进入口中。 50

别名和识别编码

Chemical Name(±)-Nicotine
CAS Number22083-74-5
Synonym {uni_hamburg} (R,S)-Nicotine 3-(1-Methyl-2-pyrrolidinyl)pyridine (±)-Nicotine DL-Nicotine 3-((R,S)-1-Methyl-pyrrolidin-2-yl)-pyridine (?)-Nicotine (±)-1-Methyl-2-(3-pyridyl)pyrrolidine Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (+-)- Nicotine, (±)- 3-(1-methyl-pyrrolidin-2-yl)-pyridine dl-beta-Nicotine Pyridine, 3-(1-methyl-2-pyrrolidinyl)- 1-Methyl-2-(3-pyridyl)pyrrolidine Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (±)- (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine Nicotin (±)-1-Methyl-2-(3-pyridyl)-pyrrolidin (±)-3-(1-Methyl-2-pyrrolidinyl)-pyridin (?)-3-(1-Methyl-2-pyrrolidinyl)pyridine (±)-Nicotine
MDL NumberMFCD00065370
Beilstein Registry Number82108
PubChem Substance ID24897418
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分类

  • {SNA} Agonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, N, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators
  • Mutagenesis Research Chemicals
  • {SNA} Agonists, Bioactive Small Molecule Alphabetical Index, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, N, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {Chemicalbook} 生物化学品: 生

产品应用

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相关文献及参考

  • Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002),
  • Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005),
  • Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005),
  • Short: II/2 Title: Magnetic Properties of Coordination and Organometallic Transition Metal Compounds Author: König, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/2 Year: 1966 ISBN: 3-540-03593-1 ISBN: 978-3-540-03593-0 Internet Resource: DOI:10.1007/b19948 RefComment: 170 figs., XII, 578 pages. Hardcover Abstract: The data compiled refer to susceptibility measurements (susceptibility, Curie-constants, magnetic moments, transition temperatures) and ESR-measurements (g-factors and other parameters of the applied spin Hamiltonian). In volume II/2 the literature from 1899 up to 1964 has been considered. Volume II/8 supplements volume II/2, taking into account the data on magnetic susceptibilities and ESR parameters published in the p eriod 1964 to 1968. The following subvolumes II/10,II/11, II/12 supplement data up to 1974.
  • Short: II/27B Title: Diamagnetic Susceptibility of Organic Compounds, Oils, Paraffins and Polyethylenes Author: Kumar, M.; Gupta, R. Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27B Year: 2008 Keyword: diamagnetic susceptibility; organic compounds ISBN: 978-3-540-44359-9 (print) ISBN: 978-3-540-45860-9 (online) Internet Resource: doi:10.1007/978-3-540-45860-9 RefComment: VIII, 503 p. With CD-ROM., Hardcover RefComment: Written for: Scientists and researchers in the fields of physics, chemistry, materials science RefComment: Supplement and Revised Editon to II/16 Abstract: The volume II/27 has been divided into three subvolumes according to the classes of compounds: Subvolume A: Diamagnetic susceptibility and magnetic anisotropy of inorganic and organometallic compounds; Subvolume B: Diamagnetic susceptibility of organic compounds, oils, paraffins

安全信息

WGK Germany3
RTECSQS5257500
GHS Symbol
Hazard statements
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H310 Fatal in contact with skin 皮肤接触致命
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P301+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes T+,N
Risk Statements
  • R51/53
  • R25 Toxic if swallowed 吞咽有毒
  • R27 Very toxic in contact with skin 与皮肤接触极毒
Restrict 剧毒化学品 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 50,93,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 50,93,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 50,93,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 50,93,1934

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules

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