• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Ephedra sinica, Ligands and Metal Complex Precursors, Organic and Printed Electronics, Phytochemicals by Plant (Food/Spice/Herb), Synthetic Tools and Reagents, 材料科学, 细胞生物学, 营养研究
• {SNA} Alphabetical Listings, Bioactive Small Molecules, Flavors and Fragrances, Q, Q-Z, 细胞生物学
• {SNA} Alphabetical Listings, Flavors and Fragrances, Q-Z
• {SNA} Bioactive Small Molecules, Ephedra sinica, Ligands and Metal Complex Precursors, Materials Science, Nutrition Research,
• {SNA} Alphabetical Listings, Bioactive Small Molecules, Flavors and Fragrances, Q,
• Bioactive Small Molecules,

产品应用

• 溶剂。测定矿物的折光率。分离钒酸盐及砷酸盐。检定木质素。显微结晶方法测定砷酸。锆、钍、铈、镧、钕和镨的沉淀剂。测试铋、锑、镍、铼、钛、铂、钯、铱、锇和金等。有机合成。染料制造。医药抗疟药。标本防腐。

相关文献及参考

• {ALF
• A novel radical alkylation of quinoline and related heterocycles in the 2-position uses free radicals generated by reaction of alkyl iodides with hydrogen peroxide in DMSO: J. Org. Chem., 54, 5224 (1989). For silver(II)-promoted radical alkylation, see: Trimethyl­acetic acid, A10776.
• Li or Na in liquid ammonia give the 1,4-dihydro-derivative: Tetrahedron Lett., 2395 (1975), whereas pyridine-borane gives 1,2,3,4-tetrahydroquinoline: Synthesis, 447 (1978). Reaction with NaBH4 and a carboxylic acid results in "reduction-alkylation" to a 1-alkyl-1,2,3,4-tetrahydroquinoline: Synthesis, 650 (1975); compare also Sodium cyanoborohydride, 87839. However, selective hydrogenation of the benzene ring over PtO2 in co
• Enhances selectivity of reduction of alkynes to alkenes over Lindlar catalyst: Org. Synth. Coll., 5, 880 (1973). In combination with sulfur, is a catalyst poison for the Rosenmund reduction of a
• Li or Na in liquid ammonia give the 1,4-dihydro-derivative: Tetrahedron Lett., 2395 (1975), whereas pyridine-borane gives 1,2,3,4-tetrahydroquinoline: Synthesis, 447 (1978). Reaction with NaBH4 and a carboxylic acid results in "reduction-alkylation" to a 1-alkyl-1,2,3,4-tetrahydroquinoline: Synthesis, 650 (1975); compare also Sodium cyanoborohydride, 87839. However, selective hydrogenation of the benzene ring over PtO2 in conc. HCl was reported: J. Am. Chem. Soc., 96, 2256 (1974).
• Reacts with acyl halides in the presence of an alkali cyanide to give Reissert compounds. For reviews, see: Chem. Rev., 55, 511 (1955); Adv. Het. Chem., 9, 1 (1968); 24, 187 (1979). See also Isoquinoline, B21279. For the formation of Reissert compounds under phase-transfer conditions, with a variety of carbonyl, sulfonyl and phosphoryl halides, see: Synthesis, 497 (1977). For 'direct' cyanation by a modified Reissert procedure, using DBU, see: J. Org. Chem., 49, 4056 (1984).
• Dehydrohalogenation base; see, e.g.: Org. Synth. Coll., 4, 608 (1963).

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7770 mg/kg/37W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,329,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 gm/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   68,785,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 gm/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   68,785,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9042 ug/kg/15D-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 78,139,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 331 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,848,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 540 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   9,111,1989

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Embryo
DOSE/DURATION           : 460 mmol/L/10M (Continuous)
REFERENCE :
   CHROAU Chromosoma.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1939-  Volume(issue)/page/year:
   56,289,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 4,41,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volume(issue)/page/y

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 110 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volu

其他信息

• 概述:喹啉也叫做苯并吡啶、氮杂萘，为吡啶与苯并联的化合物，是一个杂环芳香性有机化合物。常温下为具有强烈臭味的无色吸湿性液体，暴露在光下，会慢慢变成淡黄色，进一步变成棕色，分子式是C9H7N，微溶于水，易溶于乙醇、乙醚等很多有机溶剂，有两种并合方式,分别称为喹啉和异喹啉。它们存在于煤焦油和骨焦油内，由煤焦油制得的粗喹啉含有约4％的异喹啉。异喹啉的熔点26.5℃，沸点242.2℃(743毫米汞柱)，密度1.0986g／cm3（20℃），其气味与喹啉完全不同。二者都具有碱性，异喹啉比喹啉碱性更强，都可以与强酸生成盐，如苦味酸盐和重铬酸盐；与卤代烷形成四级铵盐等，喹啉的芳香性很强,苯环部分容易在5,8两位上发生亲电取代反应，例如在硝化或磺化时，产生5-和8-硝基和磺基喹啉。吡啶环部分稳定，在氧化时，苯环被破坏，而吡啶环不变。喹啉的红外光谱在3.27微米外有一个与1-甲基萘相似的吸收峰，异喹啉与萘的红外吸收很相似。异喹啉的性质与喹啉近似，硝化和磺化在苯环的5位上发生，亲核反应则在1位上发生，如与氨基钠反应，生成1-氨基异喹啉，而喹啉在2位上氨基化。工业上常用喹啉的酸性硫酸盐溶于乙醇，而异喹啉的酸性硫酸盐则不溶的性质来分离。 喹啉是有毒性的，短时间暴露在喹啉蒸汽中会导致鼻子、眼睛和呼吸道被腐蚀，也可能导致头昏和恶心。长时间暴露的影响还不确定，不过喹啉与肝损伤有一定的关系。
• 下游产品:3-氨基奎宁环盐酸盐 --> 喹啉酸 --> 4-羟基苯乙烯 --> 8-羟基喹啉 --> 4-氰基苯乙烯 --> 2-氨基喹啉 --> 5-氨基苯并噻吩 --> 4-溴喹啉 --> 4-硝基苯乙烯 --> 3-氟喹啉-4-羧酸 --> 4-氨基喹啉 --> 3,4-二甲基噻吩并[2,3-B]噻吩-2-甲醛 --> 4-氯-6-三氟甲基嘧啶 --> 2-羟基喹啉 --> 2-溴喹啉 --> 1-甲基-5-硝基-1H-吲哚 --> 铬黑 T --> 灭草喹 --> 硝酸硫胺 --> 盐酸硫胺 --> 1-甲基-1,2,3,4-四氢喹啉-6-甲醛 --> 4-硝基喹啉-N-氧化物 --> 8-羟基喹啉铜 --> 3-氰基喹啉 --> 4-甲氧基喹啉 --> 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 --> 喹啉-8-磺酰氯 --> 5-氨基吲哚 --> (Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯 --> 2-氰基喹啉 --> 5-溴-6-氯烟酸 --> 2-苯基喹啉 --> 喹哪啶酸 --> 3-甲基呋喃 --> 喹啉黄 --> 4-乙烯基-2-甲氧基苯酚 --> 异氰酸己酯
• Sigma Aldrich:91-22-5(sigmaaldrich)
• 蒸气压:0.07 mm Hg ( 20 °C)
• {Chemicalbook
• 灭火剂:干粉、泡沫、二氧化碳、砂土、雾状水。
• Acros Organics:喹啉 Quinoline, 96%(91-22-5)
• 可燃性危险特性:明火可燃; 高热分解有毒的氧化氮气体
• 日久变黄，有特殊不愉快的气味。有吸湿性，能从空气中吸收22%水分。能随水蒸气挥发。见光或露置后色变深，如显著变色，必须重新蒸馏。弱碱性，对酚酞呈中性，与强酸形成可溶性盐类。能与醇、醚及二硫化碳混溶，易溶于热水，难溶于冷水，能溶解硫、磷和三氧化砷。中等毒，半数致死量(大鼠，经口)460mg/kg。
• F:8
• 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 喹啉 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最
• 方法一:喹啉可从煤焦油的洗油或萘油中提取。萘油馏分和洗油馏分用稀硫酸洗涤，得到硫酸喹啉盐基溶液，用蒸气蒸去除中性油等杂质，再用碱或氨分解。分离出来的粗喹啉及其同系物经脱水后，用高产蒸馏塔精馏，切取沸程为237.5-239.5℃的馏分段，可以得到含喹啉83%、异喹啉15%的粗喹啉。将粗喹啉用浓度为60%的磷酸水溶液处理，冷却后过滤，即得到喹啉磷酸盐结晶。用碱分解后，产品纯度为9
• {Che
• 图谱信息:喹啉(91-22-5)红外
• 日久变黄，有特殊不愉快的气味。有吸湿性，能从空气中吸收22%水分
• 毒性分级:高毒