4,8-Dihydroxyquinoline-2-Carboxylic Acid 4,8-二羟基喹啉-2-甲酸

CAS 59-00-7 MFCD00006754

化学结构图

59-00-7
SMILES: O=C(O)c1cc(=O)c2cccc(O)c2[nH]1

化学属性

Mol. FormulaC10H7NO4
Mol. Weight205.17
Density1.569
Melting Point297-298 °C (dec.)(lit.)

别名和识别编码

Chemical Name4,8-Dihydroxyquinoline-2-Carboxylic Acid
CAS Number59-00-7
Synonym XANTHURIC ACID NSC 401570 4,8-二羥-2-喹啉甲酸 XANTHURENIC ACID 4,8-Dihydroxy-2-quinolinecarboxylic Acid 4,8-DIHYDROXY-2-QUINOLINECARBOXYLIC ACID 2-Quinolinecarboxylic acid, 4,8-dihydroxy- 4,8-dihydroxy-quinaldicaci 4,8-二羟基喹啉甲酸 4,8-Dihydroxyquinaldinic acid 4,8-Dihydroxyquinoline-2-carboxylic acid 4,8-二羟基喹啉-2-甲酸 8-hydroxykynurenicacid 4,8-DIHYDROXYQUINOLINE-2 Xanthuric acid 黃尿酸 TIMTEC-BB SBB003498 4,8-二羟基喹啉-2-甲酸 4,8-二羟基喹啉甲酸 8-Hydroxykynurenic acid 黄尿酸
EC Number200-410-1
Beilstein Registry Number22(3/4)2513
MDL NumberMFCD00006754
PubChem Substance ID5699
Chemical Name Translation4,8-二羟基喹啉-2-甲酸
Reaxys-RN185954
Merck Number10068
Wiswesser Line NotationT66 BNJ CVQ EQ JQ
LabNetwork Molecule IDLN00193962
InChIInChI=1S/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15)
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分类

  • Amines
  • Heterocycles
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines
  • Aromatics

产品应用

  • Excreted by pyridoxine-deficient animals after the ingestion of tryptophan.

相关文献及参考

  • Aquilina, J., et al.: Biochemistry, 39, 16176 (2000),
  • Merck:10068
  • Merck:10068 Beilstein:22(3/4)2513
  • Roberts, J., et al.: Photochem. Photobiol., 74, 740 (2001),
  • [1]. Copeland CS, et al. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology. 2013 Mar;66:133-42.

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUZ9275000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 108,924,1963

其他信息

  • 图谱信息:4,8-二羟基喹啉-2-甲酸(59-00-7)红外图谱(IR2) 4,8-二羟基喹啉-2-甲酸(59-00-7)红外图谱(IR1) 4,8-二羟基喹啉-2-甲酸(59-00-7)质谱(MS) 4,8-二羟基喹啉-2-甲酸(59-00-7)核磁图( 13 CNMR)
  • 上游原料:乙醚 --> 硫酸 --> 石油醚 --> 甲苯 --> 硫酸钠 --> 硫酸镁 --> 苯 --> 磷酸 --> 亚硫酸氢钠 --> 碘化钾 --> 矿物油 --> 邻甲氧基苯胺 --> 碘化氢 --> 卑磷酸 --> 草酰乙酸二乙酯钠盐
  • 4,8-二羟基喹啉-2-甲酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 X0054 尿酸 Xanthurenic Acid 1G 643元 2010/06/21 115090050 4,8-二羟基喹啉-2-甲酸 4,8-Dihydroxyquinoline-2-carboxylic acid 96% 5 GR 1902元 2010/06/21 115090010 4,8-二羟基喹啉-2-甲酸 4,8-Dihydroxyquinoline-2-carboxylic acid 96% 1 GR 502元
  • Sigma Aldrich:59-00-7(sigmaaldrich)
  • MOL 文件:59-00-7.mol
  • TCI Shanghai:4,8-二羟基喹啉-2-甲酸 Xanthurenic Acid,>;95.0%(T)(59-00-7)
  • Acros Organics:4,8-二羟基喹啉-2-羧酸 4,8-Dihydroxyquinoline-2-carboxylic acid, 96%(59-00-7)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  5. C8 to C10 - Quinolines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quinolines 喹啉
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mGluR  (代谢型谷氨酸受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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