7-Iodo-8-hydroxyquinoline-5-sulfonic acid 7-碘-8-羟基喹啉-5-磺酸

CAS 547-91-1 MFCD00006793

化学结构图

547-91-1
SMILES: O=S(=O)(O)c1cc(I)c(O)c2ncccc12

化学属性

Mol. FormulaC9H6INO4S
Mol. Weight351.12
Melting Point269-270 °C
TSCAYes
Appearance 淡黄色粉末。熔点260-270℃(分解),极微溶于水、乙醇,实际上不溶于乙醚、氯仿、苯。该品1g溶于500ml冷水,溶于170ml沸水。无臭,味苦。该品作为药物是80%7-碘-8-羟基喹啉-5-磺酸和20%碳酸氢钠的混合物。
SolubilitySoluble in water (2 mg/ml).

别名和识别编码

Chemical Name7-Iodo-8-hydroxyquinoline-5-sulfonic acid
Synonym Ferron {LY} Ferron {} {LY} Ferron {} {} {LY} Ferron {} {} {} {LY} Ferron {} {} {} {} {LY} Ferron {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ferron {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006793
CAS Number547-91-1
PubChem Substance ID11043
EC Number208-938-4
Beilstein Registry Number22(3/4)3497
Merck Number4826
Reaxys-RN223832
Chemical Name Translation7-碘-8-羟基喹啉-5-磺酸
Wiswesser Line NotationT66 BNJ GSWQ II JQ
LabNetwork Molecule IDLN00189895
InChIInChI=1S/C9H6INO4S/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12/h1-4,12H,(H,13,14,15)
Canonical SMILESC1=CC2=C(C(=C(C=C2S(=O)(=O)O)I)O)N=C1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; alcohol; 1fragment
  • {SNA} Spectroscopy, UV/Vis Reagents, UV/Visible (UV/VIS) Spectroscopy, 分析/色谱, 分析试剂
  • {SNA} Analytical Reagents, Analytical/Chromatography, Spectroscopy, UV/Vis Reagents, UV/Visible (UV/VIS) Spectroscopy

产品应用

  • A reagent for the spectrophotometric determination of Fe.

相关文献及参考

  • Short: III/10a
  • Short: EINECS
  • Merck:4826
  • Merck:4826 Beilstein:22(3/4)3497

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSVC2800000
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P305+P351+P338
Signal word Danger
Hazard Codes C
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
Risk Statements
  • R34 Causes burns 会导致灼伤
UN Number UN 2585 8/PG 3 3261 2585 UN3261
Packing GroupIII
Hazard Class8
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 63,122,1938

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,495,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 63,122,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 3,44,1948

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {}

其他信息

  • Sigma Aldrich:547-91-1(sigmaaldrich)
  • 喹碘方价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30106981 7-碘-8-羟基喹啉-5-磺酸 5g 107元 2011/04/16 H0254 8-羟基-7-碘喹啉-5-磺酸 8-Hydroxy-7-iodoquinoline-5-sulfonic Acid 25G 495元
  • 上游原料:发烟硫酸 --> 次氯酸钠 --> 碘 --> 8-羟基喹啉
  • 方法一:由8-羟基喹啉经发烟硫酸磺化、碘片及次氯酸钠碘化而得。
  • 8-Hydroxy-7-iodo-5-quinolinesulfonic acid is a reagent for the extraction and spectrophotometric determination of Fe.
  • 用途二:萃取铁和光度法测定铁的试剂。
  • MSDS 信息:Ferron(547-91-1).msds
  • 用途一:用作抗阿米巴药。属卤化8-羟基喹啉类。这类抗阿米巴药通过抑制肠内共生菌而发挥抗阿米巴作用,对阿米巴痢疾产效,对肠道外阿米巴原虫无影响。近年来国外报道本类药物能引起亚急性脊髓视神经病,故该药在日本和美国已禁用。
  • 几乎无臭、无味。微溶于冷水、乙醇,溶于沸水,不溶于乙醚及油类。
  • MOL 文件:547-91-1.mol
  • 图谱信息:喹碘方(547-91-1)核磁图( 13 CNMR) 喹碘方(547-91-1)红外图谱(IR2) 喹碘方(547-91-1)红外图谱(IR1)
  • TCI Shanghai:8-羟基-7-碘-5-喹啉磺酸 8-Hydroxy-7-iodoquinoline-5-sulfonic Acid,>;98.0%(LC)(T)(547-91-1)

系列性分类


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